巨噬细胞极化
炎症
骨关节炎
细胞凋亡
促炎细胞因子
巨噬细胞
癌症研究
溴尿嘧啶
细胞生物学
免疫学
医学
组蛋白
病理
生物
体外
生物化学
替代医学
基因
作者
Yidi Xu,Xiangchao Liang,Zhipeng Li,Zhao-Sheng Wu,Jie Yang,Shidong Jia,Rui Peng,Zhenyan Li,Xiaohe Wang,Fang-Ji Luo,Jiajing Chen,Wenxiang Cheng,Peng Zhang,Zhengang Zha,Rong Zeng,Huan‐Tian Zhang
出处
期刊:Biomaterials
[Elsevier]
日期:2024-04-01
卷期号:306: 122483-122483
被引量:2
标识
DOI:10.1016/j.biomaterials.2024.122483
摘要
Bromodomain-containing protein 4 (BRD4) is the most well-studied BET protein that is important for the innate immune response. We recently revealed that targeting BRD4 triggers apoptosis in tumor-associated macrophages, but its role in synovial macrophages and joint inflammation is largely unknown. Herein, we demonstrated that BRD4 was highly expressed in the iNOS-positive M1 macrophages in the human and mouse osteoarthritis (OA) synovium, and conditional knockout of BRD4 in the myeloid lineage using Lyz2-cre; BRD4
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