生物
表观遗传学
结直肠癌
癌变
癌症
干预(咨询)
肠道菌群
癌症研究
生物信息学
肿瘤科
遗传学
免疫学
医学
基因
精神科
作者
Mritunjay Pandey,Jayanta Bhattacharyya
出处
期刊:Epigenomics
[Future Medicine]
日期:2024-02-27
标识
DOI:10.2217/epi-2023-0382
摘要
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. The occurrence of CRC is associated with various genetic and epigenetic mutations in intestinal epithelial cells that transform them into adenocarcinomas. There is increasing evidence indicating the gut microbiota plays a crucial role in the regulation of host physiological processes. Alterations in gut microbiota composition are responsible for initiating carcinogenesis through diverse epigenetic modifications, including histone modifications, ncRNAs and DNA methylation. This work was designed to comprehensively review recent findings to provide insight into the associations between the gut microbiota and CRC at an epigenetic level. These scientific insights can be used in the future to develop effective strategies for early detection and treatment of CRC.
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