组蛋白脱乙酰基酶
免疫疗法
药物发现
癌症免疫疗法
癌症
化学
表观遗传学
药品
癌症研究
药理学
计算生物学
医学
组蛋白
生物
生物化学
内科学
基因
作者
Binbin Cheng,Wei Dong Pan,Yao Xiao,Zongbao Ding,Yingxing Zhou,Xiaoting Fei,Jin Liu,Zhenhong Su,Xiaopeng Peng,Jianjun Chen
标识
DOI:10.1016/j.ejmech.2024.116129
摘要
HDAC inhibitors, which can inhibit the activity of HDAC enzymes, have been extensively studied in tumor immunotherapy and have shown potential therapeutic effects in cancer immunotherapy. To date, numerous small molecule HDAC inhibitors have been identified, but many of them suffer from limited clinical efficacy and serious toxicity. Hence, HDAC inhibitor-based combination therapies, and other HDAC modulators (e.g. PROTAC degraders, dual-acting agents) have attracted great attention with significant advancements achieved in the past few years due to their superior efficacy compared to single-target HDAC inhibitors. In this review, we overviewed the recent progress on HDAC-based drug discovery with a focus on HDAC inhibitor-based drug combination therapy and other HDAC-targeting strategies (e.g. selective HDAC inhibitors, HDAC-based dual-target inhibitors, and PROTAC HDAC degraders) for cancer immunotherapy. In addition, we also summarized the reported co-crystal structures of HDAC inhibitors in complex with their target proteins and the binding interactions. Finally, the challenges and future directions for HDAC-based drug discovery in cancer immunotherapy are also discussed in detail.
科研通智能强力驱动
Strongly Powered by AbleSci AI