Multi-centre evaluation of variation in cumulative dose assessment in reirradiation scenarios

累积剂量 核医学 累积发病率 医学 一致性(知识库) 头颈部 医学物理学 计算机科学 外科 人工智能 移植
作者
Nicholas Hardcastle,E. Vásquez Osorio,Andrew Jackson,Charles W. Mayo,Anja Einebærholm Aarberg,M. Ayadi,Francesca Belosi,Cemile Ceylan,A. Davey,P. Dupuis,Joshua Handley,Theresa Hemminger,Lone Hoffmann,Colin Kelly,C. Michailidou,Sarah Muscat,Donna H. Murrell,J. Fernández,Catherine G. Palmer,L. Placidi,Marija Popović,H.S. Rønde,Allison Selby,T. Skopidou,Natasa Solomou,J. Stroom,Christopher Thompson,Nick West,Ali Zaila,Ane L. Appelt
出处
期刊:Radiotherapy and Oncology [Elsevier BV]
卷期号:194: 110184-110184
标识
DOI:10.1016/j.radonc.2024.110184
摘要

Safe reirradiation relies on assessment of cumulative doses to organs at risk (OARs) across multiple treatments. Different clinical pathways can result in inconsistent estimates. Here, we quantified the consistency of cumulative dose to OARs across multi-centre clinical pathways.We provided DICOM planning CT, structures and doses for two reirradiation cases: head & neck (HN) and lung. Participants followed their standard pathway to assess the cumulative physical and EQD2 doses (with provided α/β values), and submitted DVH metrics and a description of their pathways. Participants could also submit physical dose distributions from Course 1 mapped onto the CT of Course 2 using their best available tools. To assess isolated impact of image registrations, a single observer accumulated each submitted spatially mapped physical dose for every participating centre.Cumulative dose assessment was performed by 24 participants. Pathways included rigid (n = 15), or deformable (n = 5) image registration-based 3D dose summation, visual inspection of isodose line contours (n = 1), or summation of dose metrics extracted from each course (n = 3). Largest variations were observed in near-maximum cumulative doses (25.4 - 41.8 Gy for HN, 2.4 - 33.8 Gy for lung OARs), with lower variations in volume/dose metrics to large organs. A standardised process involving spatial mapping of the first course dose to the second course CT followed by summation improved consistency for most near-maximum dose metrics in both cases.Large variations highlight the uncertainty in reporting cumulative doses in reirradiation scenarios, with implications for outcome analysis and understanding of published doses. Using a standardised workflow potentially including spatially mapped doses improves consistency in determination of accumulated dose in reirradiation scenarios.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
xs发布了新的文献求助10
刚刚
yeeeee发布了新的文献求助10
1秒前
1秒前
1秒前
2秒前
雨齐发布了新的文献求助20
2秒前
量子星尘发布了新的文献求助10
2秒前
Dipsy完成签到,获得积分10
5秒前
5秒前
Air完成签到 ,获得积分10
5秒前
传奇3应助xf采纳,获得10
5秒前
miga发布了新的文献求助10
6秒前
7秒前
乐乐应助分不清季节更替采纳,获得10
7秒前
ll应助科研通管家采纳,获得10
11秒前
FashionBoy应助科研通管家采纳,获得10
12秒前
古往今来发布了新的文献求助10
12秒前
SciGPT应助科研通管家采纳,获得10
12秒前
FashionBoy应助科研通管家采纳,获得10
12秒前
隐形曼青应助科研通管家采纳,获得10
12秒前
Lucas应助科研通管家采纳,获得10
12秒前
12秒前
12秒前
12秒前
ding应助miga采纳,获得10
13秒前
小曦发布了新的文献求助10
13秒前
学术渣完成签到,获得积分10
14秒前
zzzzzzzp应助kg采纳,获得10
15秒前
16秒前
16秒前
佳佳应助byyyy采纳,获得10
17秒前
学术渣发布了新的文献求助10
17秒前
18秒前
ll应助JosephLee采纳,获得10
18秒前
19秒前
1111111发布了新的文献求助10
20秒前
21秒前
22秒前
古往今来完成签到,获得积分10
22秒前
所所应助猪猪hero采纳,获得10
23秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969574
求助须知:如何正确求助?哪些是违规求助? 3514435
关于积分的说明 11173986
捐赠科研通 3249755
什么是DOI,文献DOI怎么找? 1794979
邀请新用户注册赠送积分活动 875537
科研通“疑难数据库(出版商)”最低求助积分说明 804844