Unveiling the Spatiotemporal Diversity of the Endothelium in Development: A Multi-Omics Approach

多样性(政治) 医学院 医学 图书馆学 医学教育 计算机科学 政治学 法学
作者
Roy Jung,Chinmay M. Trivedi
出处
期刊:Circulation Research [Ovid Technologies (Wolters Kluwer)]
卷期号:134 (5): 547-549 被引量:1
标识
DOI:10.1161/circresaha.124.324328
摘要

HomeCirculation ResearchVol. 134, No. 5Unveiling the Spatiotemporal Diversity of the Endothelium in Development: A Multi-Omics Approach No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextUnveiling the Spatiotemporal Diversity of the Endothelium in Development: A Multi-Omics Approach Roy Jung and Chinmay M. Trivedi Roy JungRoy Jung Division of Cardiovascular Medicine (R.J., C.M.T.), UMass Chan Medical School, Worcester, MA. Department of Medicine (R.J., C.M.T.), UMass Chan Medical School, Worcester, MA. Translational Science Program, Morningside Graduate School of Biomedical Sciences (R.J., C.M.T.), UMass Chan Medical School, Worcester, MA. and Chinmay M. TrivediChinmay M. Trivedi Correspondence to: Chinmay M. Trivedi, MD, PhD, Division of Cardiovascular Medicine, Department of Medicine, Albert Sherman Center, AS7-1047, 368 Plantation St, Worcester, MA 01605. Email E-mail Address: [email protected] https://orcid.org/0000-0002-3544-0474 Division of Cardiovascular Medicine (R.J., C.M.T.), UMass Chan Medical School, Worcester, MA. Department of Medicine (R.J., C.M.T.), UMass Chan Medical School, Worcester, MA. Translational Science Program, Morningside Graduate School of Biomedical Sciences (R.J., C.M.T.), UMass Chan Medical School, Worcester, MA. Department of Molecular, Cell, and Cancer Biology (C.M.T.), UMass Chan Medical School, Worcester, MA. Originally published29 Feb 2024https://doi.org/10.1161/CIRCRESAHA.124.324328Circulation Research. 2024;134:547–549This article is a commentary on the followingMolecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell ResolutionFootnotesFor Sources of Funding and Disclosures, see page 549.The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Correspondence to: Chinmay M. Trivedi, MD, PhD, Division of Cardiovascular Medicine, Department of Medicine, Albert Sherman Center, AS7-1047, 368 Plantation St, Worcester, MA 01605. Email chinmay.trivedi@umassmed.eduREFERENCES1. Aird WC. Endothelial cell heterogeneity.Cold Spring Harb Perspect Med. 2012; 2:a006429. doi: 10.1101/cshperspect.a006429CrossrefMedlineGoogle Scholar2. Flaherty JT, Pierce JE, Ferrans VJ, Patel DJ, Tucker WK, Fry DL. Endothelial nuclear patterns in the canine arterial tree with particular reference to hemodynamic events.Circ Res. 1972; 30:23–33. doi: 10.1161/01.res.30.1.23LinkGoogle Scholar3. Kalucka J, de Rooij L, Goveia J, Rohlenova K, Dumas SJ, Meta E, Conchinha NV, Taverna F, Teuwen LA, Veys K, et al. Single-cell transcriptome atlas of murine endothelial cells.Cell. 2020; 180:764–779 e720. doi: 10.1016/j.cell.2020.01.015CrossrefMedlineGoogle Scholar4. Paik DT, Tian L, Williams IM, Rhee S, Zhang H, Liu C, Mishra R, Wu SM, Red-Horse K, Wu JC. Single-cell RNA sequencing unveils unique transcriptomic signatures of organ-specific endothelial cells.Circulation. 2020; 142:1848–1862. doi: 10.1161/CIRCULATIONAHA.119.041433LinkGoogle Scholar5. Janardhan HP, Saheera S, Jung R, Trivedi CM. Vascular and lymphatic malformations: perspectives from human and vertebrate studies.Circ Res. 2021; 129:131–135. doi: 10.1161/CIRCRESAHA.121.319587LinkGoogle Scholar6. Janardhan HP, Trivedi CM. Establishment and maintenance of blood-lymph separation.Cell Mol Life Sci. 2019; 76:1865–1876. doi: 10.1007/s00018-019-03042-3CrossrefMedlineGoogle Scholar7. Janardhan HP, Jung R, Trivedi CM. Lymphatic system in organ development, function, and regeneration.Circ Res. 2023; 132:1181–1184. doi: 10.1161/CIRCRESAHA.123.322867LinkGoogle Scholar8. Levsky JM, Shenoy SM, Pezo RC, Singer RH. Single-cell gene expression profiling.Science. 2002; 297:836–840. doi: 10.1126/science.1072241CrossrefMedlineGoogle Scholar9. Baysoy A, Bai Z, Satija R, Fan R. The technological landscape and applications of single-cell multi-omics.Nat Rev Mol Cell Biol. 2023; 24:695–713. doi: 10.1038/s41580-023-00615-wCrossrefMedlineGoogle Scholar10. Chen KH, Boettiger AN, Moffitt JR, Wang S, Zhuang X. RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells.Science. 2015; 348:aaa6090. doi: 10.1126/science.aaa6090CrossrefMedlineGoogle Scholar11. Moffitt JR, Bambah-Mukku D, Eichhorn SW, Vaughn E, Shekhar K, Perez JD, Rubinstein ND, Hao J, Regev A, Dulac C, et al. Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region.Science. 2018; 362:eaau5324. doi: 10.1126/science.aau5324CrossrefMedlineGoogle Scholar12. Xia C, Fan J, Emanuel G, Hao J, Zhuang X. Spatial transcriptome profiling by MERFISH reveals subcellular RNA compartmentalization and cell cycle-dependent gene expression.Proc Natl Acad Sci U S A. 2019; 116:19490–19499. doi: 10.1073/pnas.1912459116CrossrefMedlineGoogle Scholar13. Kharchenko PV, Silberstein L, Scadden DT. Bayesian approach to single-cell differential expression analysis.Nat Methods. 2014; 11:740–742. doi: 10.1038/nmeth.2967CrossrefMedlineGoogle Scholar14. Fang R, Xia C, Close JL, Zhang M, He J, Huang Z, Halpern AR, Long B, Miller JA, Lein ES, et al. Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH.Science. 2022; 377:56–62. doi: 10.1126/science.abm1741CrossrefMedlineGoogle Scholar15. Chen J, Zhang X, DeLaughter DM, Trembley MA, Saifee S, Chen J, Zhou P, Seidman C, Seidman J, Pu W. Molecular and spatial signatures of mouse embryonic endothelial cells at single-cell resolution.Circ Res. 2024; 134:529–546. doi: 10.1161/CIRCRESAHA.123.323956.LinkGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesMolecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell ResolutionJian Chen, et al. Circulation Research. 2024;134:529-546 March 1, 2024Vol 134, Issue 5 Advertisement Article InformationMetrics © 2024 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.124.324328PMID: 38422180 Originally publishedFebruary 29, 2024 KeywordsEditorialsarteriescapillarieslymphatic vesselsspatio-temporal analysisveinsPDF download Advertisement SubjectsEndothelium/Vascular Type/Nitric OxideOmics

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