The effect of abnormal secretion of DKK1 by fibroblasts on melanocytes function in vitiligo

The effect of abnormal secretion of DKK1 by fibroblasts on melanocytes function in vitiligoDear Editor, The pathogenesis of vitiligo remains unclear, 1 and in recent years, the role of dermal compartment, 2 especially fibroblasts, 2 has attracted increasing attention.Xu et al. 3 found that fibroblasts in different anatomical sites determined different skin autoimmune patterns, which strongly confirmed the importance of mesenchymal components.Yamaguchi et al. reported that DKK1 derived from fibroblasts in different anatomical sites has an effect on the function of human melanocytes, 4,5 followed by studies reporting elevated expression of DKK1 in vitiligo lesions by immunohistochemistry, 6 ELISA 7 and qRT-PCR, 8 respectively.However, there are limited studies on the specific role of fibroblasts-secreted DKK1 in the pathogenesis of vitiligo.This study aims to explore the effect of abnormal expression of DKK1 in fibroblasts on melanocyte melanin