内耳
声穿孔
微气泡
医学
圆窗
药物输送
超声波
治疗性超声
前庭系统
生物医学工程
听力学
放射科
解剖
纳米技术
材料科学
作者
Fabrice Micaletti,Jean‐Michel Escoffre,Sandrine Kerneis,Ayache Bouakaz,John J. Galvin,L. Boullaud,D. Bakhos
标识
DOI:10.1016/j.addr.2023.115145
摘要
Treating pathologies of the inner ear is a major challenge. To date, a wide range of procedures exists for administering therapeutic agents to the inner ear, with varying degrees of success. The key is to deliver therapeutics in a way that is minimally invasive, effective, long-lasting, and without adverse effects on vestibular and cochlear function. Microbubble-assisted ultrasound (“sonoporation”) is a promising new modality that can be adapted to the inner ear. Combining ultrasound technology with microbubbles in the middle ear can increase the permeability of the round window, enabling therapeutic agents to be delivered safely and effectively to the inner ear in a targeted manner. As such, sonoporation is a promising new approach to treat hearing loss and vertigo. This review summarizes all studies on the delivery of therapeutic molecules to the inner ear using sonoporation.
科研通智能强力驱动
Strongly Powered by AbleSci AI