化学
电泳剂
烷基
催化作用
亲核细胞
烷基化
卤化物
催化循环
光化学
钴
组合化学
药物化学
有机化学
作者
Shijia Gou,Chenyue Li,Tiantian Liang,Chengyi Peng,Feng Bao,Chenggui Wu,Fei Ye
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-12-05
卷期号:25 (49): 8883-8888
被引量:1
标识
DOI:10.1021/acs.orglett.3c03676
摘要
We report here a general alkylation reaction of terminal alkenes with nucleophilic cobaloxime complex catalysis under visible light irradiation. A broad range of vinyl arenes and heteroarenes, as well as a diverse set of alkyl(pseudo)halides or strained rings as alkyl electrophiles, can efficiently undergo the transformation up to the gram scale. Mechanistic study reveals the radical nature of the reaction and corroborates our design involving alkylcobaloxime as the key intermediate.
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