Mechanistic Study Reveals the Roles of Ligand and Substrate on the Pd-catalyzed C-H Bond Hydroxylation of Carboxylic Acid with Molecular Oxygen

The mechanism of the Pd(II)-catalyzed, pyridine-pyridone ligand-enabled hydroxylation of C(sp2)-H bond in pyridine-4-carboxylic acid with molecular oxygen has been studied. The elemental steps include C-H bond activation, substrate-assisted O2 oxidative...