免疫系统
免疫疗法
信使核糖核酸
生物
计算生物学
细胞生物学
免疫学
化学
生物化学
基因
作者
Zhaozhao Chen,Jinhui Shu,Yu Hu,Heng Mei
标识
DOI:10.1016/j.ymthe.2024.09.019
摘要
Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a revolutionary approach in the treatment of malignancies. Despite its remarkable successes, this field continues to grapple with challenges such as scalability, safety concerns, limited therapeutic effect, in vivo persistence, and the need for precise control over CAR expression. In the post-pandemic era of COVID-19 vaccine immunization, the application of messenger RNA (mRNA) encapsulated within lipid nanoparticles (LNP) has recently garnered significant attention as a potential solution to address these challenges. This review delves into the dynamic landscape of mRNA-LNP technology and its potential implications for CAR-engineered immune cells-based immunotherapy.
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