Impact of peritoneal dialysis and hemodialysis on mortality in patients with end‐stage renal disease: A systematic review and meta‐analysis

Abstract Introduction The mortality impact of peritoneal dialysis (PD) and hemodialysis (HD) in end‐stage renal disease (ESRD) remains uncertain. Methods A meta‐analysis comparing mortality in ESRD patients on PD versus HD was conducted, including 9 studies with 7556 HD and 2651 PD patients. Results No significant difference was found in all‐cause mortality, cardiovascular‐related mortality, or infection‐related mortality between HD and PD patients. Hemoglobin, ferritin, and iron levels were similar in groups, but HD patients had higher albumin and BUN levels ( p < 0.05). Regarding cardiovascular factors and bone minerals, total cholesterol and LDL levels were significantly lower, and calcium levels were significantly higher in the HD group compared with the PD group ( p < 0.01). Conclusion Mortality does not significantly differ between HD and PD in ESRD patients, though HD is linked to higher serum albumin levels and lower levels of total cholesterol and LDL.