抗生素
环丙沙星
细菌
两亲性
化学
抗菌剂
四环素
膜透性
庆大霉素
抗生素耐药性
微生物学
生物化学
生物
膜
有机化学
聚合物
遗传学
共聚物
作者
Cristina Minnelli,Gianmarco Mangiaterra,Emiliano Laudadio,Barbara Citterio,Samuele Rinaldi
出处
期刊:Molecules
[MDPI AG]
日期:2024-08-28
卷期号:29 (17): 4078-4078
标识
DOI:10.3390/molecules29174078
摘要
The growth of (multi)drug resistance in bacteria is among the most urgent global health issues. Monocationic amphiphilic α-hydrazido acid derivatives are structurally simple mimics of antimicrobial peptides (AMPs) with fewer drawbacks. Their mechanism of membrane permeabilization at subtoxic concentrations was found to begin with an initial electrostatic attraction of isolated amphiphile molecules to the phospholipid heads, followed by a rapid insertion of the apolar portions. As the accumulation into the bilayer proceeded, the membrane increased its fluidity and permeability without being subjected to major structural damage. After having ascertained that α-hydrazido acid amphiphiles do not interact with bacterial DNA, they were subjected to synergy evaluation for combinations with conventional antibiotics. Synergy was observed for combinations with tetracycline against sensitive S. aureus and E. coli, as well as with ciprofloxacin and colistin against resistant strains. Additivity with a remarkable recovery in activity of conventional antibiotics (from 2-fold to ≥32-fold) together with largely subtoxic concentrations of α-hydrazido acid derivatives was found for combinations with ciprofloxacin toward susceptible S. aureus and methicillin toward MRSa. However, no potentiation of conventional antibiotics was observed for combinations with linezolid and gentamicin against the corresponding resistant S. aureus and E. coli strains.
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