化学
适体
共轭体系
黄曲霉毒素
共价键
纳米技术
组合化学
色谱法
环境化学
有机化学
分子生物学
聚合物
食品科学
生物
材料科学
作者
Shilun Li,Zhu-Ying Yan,Hai‐Long Qian,Shuting Xu,Xiu‐Ping Yan
标识
DOI:10.1021/acs.analchem.4c04098
摘要
Sensitive and selective detection of trace aflatoxin B1 (AFB1) in foods is of great importance to guarantee food safety and quality but still challenging because of its trace amount and the interference from the complex food matrix. Here, we report the integration of aptamer (Apt) and an ordered 2D covalent organic framework (COF) to solid-state anodic aluminum oxide (AAO) nanochannels (Apt/COF/AAO) for selective and sensitive detection of trace AFB1. The high specificity of Apt for AFB1 led to a selective change in the surface charge of Apt/COF/AAO and in turn the current change of the nanochannel, permitting the selective and sensitive determination of trace AFB1 in complex food samples. The developed nanofluidic sensor gave a wide linear range (1-500 pg mL
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