亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Does Nociception Level Index-Guided Opioid Administration Reduce Intraoperative Opioid Consumption? A Systematic Review and Meta-Analysis

医学 荟萃分析 类阿片 置信区间 严格标准化平均差 随机对照试验 麻醉 统计的 内科学 统计 数学 受体
作者
Muhammet Selman Söğüt,İlayda Kalyoncu,Muhammet Ahmet Karakaya,Mete Manıcı,Kamil Darçın
出处
期刊:Anesthesia & Analgesia [Lippincott Williams & Wilkins]
卷期号:139 (5): 978-985 被引量:2
标识
DOI:10.1213/ane.0000000000007180
摘要

BACKGROUND: The nociception level (NOL) index is a quantitative parameter derived from physiological signals to measure intraoperative nociception. The aim of this systematic review and meta-analysis was to evaluate if NOL monitoring reduces intraoperative opioid use compared to conventional therapy (opioid administered at clinician discretion). METHODS: This meta-analysis comprises randomized clinical trials comparing NOL-guided opioid administration to conventional therapy in adult patients undergoing any type of surgery. A systematic search of PubMed, Scopus, and CENTRAL databases was conducted. The primary outcome was intraoperative opioid consumption and the effect estimate of the NOL index was measured using the standardized mean difference (SMD) where 0.20 is considered a small and 0.80 a large effect size. A random-effects model with Hartung-Knapp-Sidik-Jonkman adjustment was applied to estimate the treatment effect. Heterogeneity was explored clinically and statistically (using the inconsistency I ² statistic, prediction intervals, and influence analysis). The quality (certainty) of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) guidelines methodology. RESULTS: This review comprised 9 trials (519 patients). The intraoperative opioid SMD (NOL monitoring versus conventional therapy) was −0.26 (95% confidence interval [CI], −0.82 to 0.30; P = .31; low certainty of evidence). We observed substantial clinical (intraoperative opioid regimens) and statistical heterogeneity with the I ² statistic being 86% (95% CI, 75%–92%). The prediction interval was between −1.95 and 1.42 indicating where the SMD between NOL and conventional therapy would lie if a similar study were conducted in the future. CONCLUSIONS: This meta-analysis does not provide evidence supporting the role of NOL monitoring in reducing intraoperative opioid consumption.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
12秒前
Qian完成签到 ,获得积分10
16秒前
情怀应助Ying采纳,获得20
33秒前
52秒前
1分钟前
科研通AI5应助忧虑的安青采纳,获得10
1分钟前
juejue333完成签到,获得积分10
1分钟前
1分钟前
1分钟前
Ying发布了新的文献求助20
1分钟前
1分钟前
Betty发布了新的文献求助10
1分钟前
Betty完成签到,获得积分10
2分钟前
科目三应助科研通管家采纳,获得10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
SciGPT应助科研通管家采纳,获得10
2分钟前
笨笨完成签到,获得积分10
2分钟前
2分钟前
2分钟前
思源应助嘿嘿嘿侦探社采纳,获得10
2分钟前
3分钟前
3分钟前
3分钟前
gyh发布了新的文献求助10
3分钟前
孤独的涵柳完成签到 ,获得积分10
3分钟前
3分钟前
gyh完成签到,获得积分20
3分钟前
4分钟前
科研通AI2S应助科研通管家采纳,获得30
4分钟前
Owen应助科研通管家采纳,获得10
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
4分钟前
4分钟前
4分钟前
搜集达人应助喜欢对你笑采纳,获得10
4分钟前
隐形曼青应助科研通管家采纳,获得10
6分钟前
科研通AI2S应助科研通管家采纳,获得10
6分钟前
老石完成签到 ,获得积分10
7分钟前
7分钟前
CipherSage应助科研通管家采纳,获得10
8分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968504
求助须知:如何正确求助?哪些是违规求助? 3513278
关于积分的说明 11167214
捐赠科研通 3248660
什么是DOI,文献DOI怎么找? 1794386
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804638