阿克曼西亚
药理学
炎症
某种肠道细菌
姜黄素
化学
结肠炎
生物利用度
溃疡性结肠炎
医学
免疫学
肠道菌群
乳酸菌
生物化学
疾病
病理
发酵
作者
Miaodeng Liu,Jinhui Zou,H. Li,Yunfan Zhou,Qiying Lv,Qian Cheng,Jia Liu,Lin Wang,Zheng Wang
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2024-07-12
卷期号:10 (28)
标识
DOI:10.1126/sciadv.adn1745
摘要
Rapid drug clearance and off-target effects of therapeutic drugs can induce low bioavailability and systemic side effects and gravely restrict the therapeutic effects of inflammatory bowel diseases (IBDs). Here, we propose an amplifying targeting strategy based on orally administered gallium (Ga)-based liquid metal (LM) nano-agents to efficiently eliminate reactive oxygen and nitrogen species (RONS) and modulate the dysregulated microbiome for remission of IBDs. Taking advantage of the favorable adhesive activity and coordination ability of polyphenol structure, epigallocatechin gallate (EGCG) is applied to encapsulate LM to construct the formulations (LM-EGCG). After adhering to the inflamed tissue, EGCG not only eliminates RONS but also captures the dissociated Ga to form EGCG-Ga complexes for enhancive accumulation. The detained composites protect the intestinal barrier and modulate gut microbiota for restoring the disordered enteral microenvironment, thereby relieving IBDs. Unexpectedly, LM-EGCG markedly decreases the Escherichia_Shigella populations while augmenting the abundance of Akkermansia and Bifidobacterium , resulting in favorable therapeutic effects against the dextran sulfate sodium-induced colitis.
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