免疫系统
外围设备
细胞生物学
周边公差
癌症研究
生物
免疫学
免疫耐受
医学
内科学
作者
Md Moazzem Hossain,Paul T. King,Justin Hackett,Herv�e C. G�erard,Rajmund Michal Niwinski,Lan Wu,Luc Van Kaer,Gregory Dyson,Heather M. Gibson,Alexander D. Borowsky,Eric Sebzda
标识
DOI:10.1073/pnas.2404916121
摘要
Identifying tumor-mediated mechanisms that impair immunity is instrumental for the design of new cancer therapies. Regulatory T cells (Tregs) are a key component of cancer-derived immune suppression; however, these lymphocytes are necessary to prevent systemic autoimmunity in mice and humans, and thus, direct targeting of Tregs is not a clinical option for cancer patients. We have previously demonstrated that excising transcription factor Kruppel-like factor 2 (
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