Early detection of necrosis in low-enhanced pancreatic parenchyma using contrast-enhanced computed tomography was a better predictor of clinical outcomes than pancreatic inflammation: a multicentric cohort study of severe acute pancreatitis

We aim to assess the early use of contrast-enhanced computed tomography (CECT) of patients with severe acute pancreatitis (SAP) using the computed tomography severity index (CTSI) in prognosis prediction. The CTSI combines quantification of pancreatic and extrapancreatic inflammation with the extent of pancreatic necrosis. Post-hoc retrospective analysis of a large, multicentric database (44 institutions) of SAP patients in Japan. The area under the curve (AUC) of the CTSI for predicting mortality and the odds ratio (OR) of the extent of pancreatic inflammation and necrosis were calculated using multivariable analysis. In total, 1097 patients were included. The AUC of the CTSI for mortality was 0.65 (95% confidence interval [CI:] [0.59-0.70]; p<0.001). In multivariable analysis, necrosis 30-50% and >50% in low-enhanced pancreatic parenchyma (LEPP) was independently associated with a significant increase in mortality, with OR 2.04 and 95% CI 1.01-4.12 (P<0.05) and OR 3.88 and 95% CI 2.04-7.40 (P<0.001), respectively. However, the extent of pancreatic inflammation was not associated with mortality, regardless of severity. The degree of necrosis in LEPP assessed using early CECT of SAP was a better predictor of mortality than the extent of pancreatic inflammation.