Stem cell-based therapy and its potential in perioperative neurocognitive disorders

神经认知 斯科普斯 神经炎症 围手术期 医学 首脑会议 梅德林 精神科 内科学 炎症 认知 外科 政治学 自然地理学 法学 地理
作者
Penghui Wei,Min Jia,P Liu,Liying Meng,Jianjun Li,Jianjun Yang
出处
期刊:BJA: British Journal of Anaesthesia [Elsevier BV]
卷期号:131 (4): e139-e142
标识
DOI:10.1016/j.bja.2023.07.014
摘要

Editor—Perioperative brain health is becoming a significant global health concern, with rapidly growing numbers of ageing patients receiving surgical procedures. Perioperative neurocognitive disorders (PNDs) are the most common postoperative neuropsychiatric complications among these ageing individuals. 1 Mahanna-Gabrielli E. Schenning K.J. Eriksson L.I. et al. State of the clinical science of perioperative brain health: report from the American society of anesthesiologists brain health initiative summit 2018. Br J Anaesth. 2019; 123: 464-478 Abstract Full Text Full Text PDF PubMed Scopus (113) Google Scholar Peripheral inflammation induced by surgical trauma can break down the integrity of the blood–brain barrier and cause a neuroinflammatory cascade, leading to brain damage. 2 Yang T. Velagapudi R. Terrando N. Neuroinflammation after surgery: from mechanisms to therapeutic targets. Nat Immunol. 2020; 21: 1319-1326 Crossref PubMed Scopus (95) Google Scholar Anti-inflammatory strategies have been explored as preventive and therapeutic approaches for PNDs 1 Mahanna-Gabrielli E. Schenning K.J. Eriksson L.I. et al. State of the clinical science of perioperative brain health: report from the American society of anesthesiologists brain health initiative summit 2018. Br J Anaesth. 2019; 123: 464-478 Abstract Full Text Full Text PDF PubMed Scopus (113) Google Scholar ; however, potential risks include immunosuppression and impaired wound healing. 2 Yang T. Velagapudi R. Terrando N. Neuroinflammation after surgery: from mechanisms to therapeutic targets. Nat Immunol. 2020; 21: 1319-1326 Crossref PubMed Scopus (95) Google Scholar Moreover, anti-inflammatory strategies are unlikely to aid repair or regeneration of already damaged neural tissues after surgery. Owing to a lack of identified key pathogenic mechanisms and molecular pathways that modulate disease progression, traditional pharmacological interventions focusing on small molecules or inflammation-based treatment for PNDs have had limited success. 3 Eckenhoff R.G. Maze M. Xie Z. et al. Perioperative neurocognitive disorder: state of the preclinical science. Anesthesiology. 2020; 132: 55-68 Crossref PubMed Scopus (94) Google Scholar Recent failure to translate anti-inflammatory therapies from preclinical studies to clinical settings has prompted exploration of novel therapeutic strategies. 4 Takazawa T. Horiuchi T. Orihara M. et al. Prevention of postoperative cognitive dysfunction by minocycline in elderly patients after total knee arthroplasty: a randomized, double-blind, placebo-controlled clinical trial. Anesthesiology. 2023; 138: 172-183 Crossref PubMed Scopus (5) Google Scholar
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
香蕉觅云应助momo采纳,获得10
2秒前
3秒前
4秒前
爆米花应助李春鸿采纳,获得10
7秒前
LJJ发布了新的文献求助10
8秒前
9秒前
10秒前
11秒前
11秒前
Ava应助YYH采纳,获得10
11秒前
量子星尘发布了新的文献求助10
11秒前
小田心完成签到,获得积分10
11秒前
14秒前
小田心发布了新的文献求助10
14秒前
WYH发布了新的文献求助10
15秒前
一方通行发布了新的文献求助10
15秒前
SherlockHe发布了新的文献求助10
16秒前
FashionBoy应助热情的达采纳,获得10
16秒前
19秒前
lelelele发布了新的文献求助10
20秒前
拜拜完成签到,获得积分10
21秒前
21秒前
扶苏完成签到,获得积分10
21秒前
23秒前
mmm完成签到,获得积分20
24秒前
momo发布了新的文献求助10
24秒前
24秒前
一方通行完成签到,获得积分10
24秒前
xiaosu完成签到,获得积分10
25秒前
小马甲应助yyy采纳,获得10
28秒前
热情的达发布了新的文献求助10
28秒前
Hello应助任性的咖啡采纳,获得10
29秒前
29秒前
墨墨完成签到,获得积分10
29秒前
30秒前
cangy完成签到,获得积分10
31秒前
岸部完成签到,获得积分10
31秒前
在水一方应助WYH采纳,获得10
32秒前
33秒前
搜集达人应助胡航航采纳,获得10
33秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989334
求助须知:如何正确求助?哪些是违规求助? 3531428
关于积分的说明 11253936
捐赠科研通 3270119
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173