Novel formats of antibody conjugates: recent advances in payload diversity, conjugation, and linker chemistry

Introduction In the field of bioconjugates, the focus on antibody – drug conjugates (ADCs) with novel payloads beyond the traditional categories of potent cytotoxic agents is increasing. These innovative ADCs exhibit various molecular formats, ranging from small-molecule payloads, such as immune agonists and proteolytic agents, to macromolecular payloads, such as oligonucleotides and proteins.