Serum cytokines and neutrophil-to-lymphocyte ratio as predictive biomarkers of benefit from PD-1 inhibitors in gastric cancer

医学 内科学 淋巴细胞 化疗 单变量分析 癌症 胃肠病学 免疫疗法 预测标记 免疫学 中性粒细胞与淋巴细胞比率 肿瘤科 多元分析
作者
Yidan Hou,Xiaoli Li,Yudan Yang,Hao Shi,Shaofang Wang,Ming Gao
出处
期刊:Frontiers in Immunology [Frontiers Media]
卷期号:14 被引量:11
标识
DOI:10.3389/fimmu.2023.1274431
摘要

Background Immunotherapy is significantly revolutionizing cancer treatment and demonstrating promising efficacy in gastric cancer (GC) patients. However, only a subset of patients could derive benefits from targeted monoclonal antibody therapy against programmed death receptor 1 (PD-1). This study aims to identify suitable serum cytokines and blood cell ratios as predictive biomarkers to aid in the selection of GC patients likely to benefit from PD-1 inhibitors. Materials and methods This retrospective study included 41 GC patients who received PD-1 inhibitors combined with chemotherapy, 36 GC patients treated solely with chemotherapy, and 33 healthy controls. The study assessed the levels of seven cytokines: interleukin-2 (IL-2), IL-4, IL-6, IL-10, IL-17A, tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), and various inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), total lymphocyte count (TLC), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR). Measurements were obtained using the inpatient system. Univariate and multivariate Cox regression analyses were performed to evaluate the predictive significance of these hematologic parameters for clinical outcomes. Results Levels of IL-6, IL-10, TNF-α, NLR, and PLR were significantly elevated in GC patients compared to healthy controls, while TLC and LMR were higher in the control group. Among the 41 patients receiving PD-1 inhibitors and chemotherapy, baseline IL-2 was associated with OS and PFS. Additionally, IL-6 and IL-17A correlated with OS, while NLR was linked to PFS (all P<0.05). These factors were identified as independent prognostic indicators in both univariate and multivariate analyses. Furthermore, almost all cytokine levels increased following the initiation of PD-1 inhibitor treatment. Conclusions The introduction of PD-1 inhibitors alongside chemotherapy in GC impacts serum cytokine levels. IL-2, IL-6, IL-17A, and NLR exhibit potential as reliable circulating predictive biomarkers for identifying patients who may benefit from PD-1 inhibitors combined with chemotherapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
韩麒嘉完成签到 ,获得积分10
2秒前
聪慧的凝海完成签到 ,获得积分0
11秒前
11秒前
wwb发布了新的文献求助10
14秒前
phil完成签到 ,获得积分10
14秒前
22秒前
高高菠萝完成签到 ,获得积分10
22秒前
滴滴滴完成签到 ,获得积分10
22秒前
yangsi完成签到 ,获得积分10
25秒前
量子星尘发布了新的文献求助10
26秒前
29秒前
酷炫葵阴发布了新的文献求助10
34秒前
ORANGE完成签到,获得积分10
36秒前
思源应助松松采纳,获得20
40秒前
共享精神应助酷炫葵阴采纳,获得10
42秒前
丝丢皮得完成签到 ,获得积分10
43秒前
44秒前
xfy完成签到,获得积分10
48秒前
阳炎完成签到,获得积分10
50秒前
行云流水完成签到,获得积分10
51秒前
52秒前
冷酷尔琴发布了新的文献求助10
56秒前
青水完成签到 ,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
1分钟前
冷酷尔琴完成签到,获得积分10
1分钟前
onevip完成签到,获得积分0
1分钟前
小莫完成签到 ,获得积分10
1分钟前
1分钟前
theseus完成签到,获得积分10
1分钟前
胡楠完成签到,获得积分10
1分钟前
北国雪未消完成签到 ,获得积分10
1分钟前
李振博完成签到 ,获得积分10
1分钟前
1分钟前
雪妮完成签到 ,获得积分10
1分钟前
松松发布了新的文献求助20
1分钟前
1分钟前
iwsaml完成签到 ,获得积分10
1分钟前
Caden完成签到 ,获得积分10
1分钟前
xmhxpz完成签到,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038029
求助须知:如何正确求助?哪些是违规求助? 3575740
关于积分的说明 11373751
捐赠科研通 3305559
什么是DOI,文献DOI怎么找? 1819224
邀请新用户注册赠送积分活动 892652
科研通“疑难数据库(出版商)”最低求助积分说明 815022