间充质干细胞
炎症
间质细胞
巨噬细胞
巨噬细胞极化
免疫系统
细胞生物学
生物
先天免疫系统
干细胞
免疫学
癌症研究
体外
生物化学
作者
Dongdong Ti,Jun Ho Yi,Huihua Chen,Haojie Hao,Chunmeng Shi
出处
期刊:Current stem cell research & therapy
[Bentham Science]
日期:2023-09-19
卷期号:19 (6): 894-905
被引量:1
标识
DOI:10.2174/1574888x18666230811093101
摘要
Abstract: Mesenchymal stem/stromal cells (MSCs) have exhibited potential for treating multiple inflammation- related diseases (IRDs) due to their easy acquisition, unique immunomodulatory and tissue repair properties, and immune-privileged characteristics. It is worth mentioning that MSCs release a wide array of soluble bioactive components in the secretome that modulate host innate and adaptive immune responses and promote the resolution of inflammation. As the first line of defense, macrophages exist throughout the entire inflammation process. They continuously switch their molecular phenotypes accompanied by complementary functional regulation ranging from classically activated pro-inflammatory M1-type (M1) to alternatively activated anti-inflammatory M2-type macrophages (M2). Recent studies have shown that the active intercommunication between MSCs and macrophages is indispensable for the immunomodulatory and regenerative behavior of MSCs in pharmacological cell therapy products. In this review, we systematically summarized the emerging capacities and detailed the molecular mechanisms of the MSC-derived secretome (MSC-SE) in immunomodulating macrophage polarization and preventing excessive inflammation, providing novel insights into the clinical applications of MSC-based therapy in IRD management.
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