Remimazolam besylate inhibits human lung cancer cell proliferation, migration, and induces apoptosis in vitro

Perioperative factors including surgical stress and anaesthetics are involved in cancer recurrence and metastasis after surgery, resulting in poor post-surgical outcomes and even death. Indeed, unlike propofol, inhalation anaesthetic isoflurane promoted malignancy in several cancer cells reported previously.1 2 Remimazolam besylate is a novel benzodiazepine derivative which acts on GABA-A receptors.3 The impact of remimazolam besylate on human cancer cells is unknown. This study aimed to examine the effect of remimazolam on cancer cell proliferation, migration, and apoptosis of human lung carcinoma (A549) cells.