The association between n‐3 polyunsaturated fatty acid intakes and asthma in US children and adolescents: A cross‐sectional study from NHANES

Abstract Background Asthma is an inflammatory disease. The potential of n‐3 polyunsaturated fatty acids (PUFAs) to alleviate asthma symptoms through their anti‐inflammatory effects and immune modulation has been explored. However, the precise role of dietary n‐3 PUFAs in childhood and adolescent asthma remains unclear. Objective This study aimed to evaluate the association between dietary n‐3 PUFAs intake and asthma in children and adolescents in the United States. Methods We conducted a cross‐sectional analysis of 8543 children and adolescents from the National Health and Nutrition Examination Survey (NHANES) between 2013 and 2020 by adjusting for covariates and using multivariate logistic regression, restricted cubic spline, threshold effects, and subgroup analyses. Results Among 8354 participants, 1456 (16.5%) self‐reported diagnosis of asthma by a healthcare provider. After adjusting for potential confounding factors, compared with individuals in the lowest n‐3 PUFA consumption group (T1, <26.07 mg/kg/day), the adjusted odds ratio (OR) for asthma was 0.71 (95% CI: 0.6–0.84, p < .001) in the second group (T2, 26.07–48.93 mg/kg/day) and 0.58 (95% CI: 0.47–0.73, p < .001) in the third group (T3, >48.93 mg/kg/day). Furthermore, a nonlinear (L‐shaped) relationship was observed between n‐3 PUFA intake and asthma ( p = .009), with subgroup and sensitivity analyses confirming the stability of the results. In the threshold analysis, a critical turning point was observed at approximately 59.0 mg/kg/day (OR = 0.984, 95% CI: 0.977–0.991, p < .001). Conclusion Dietary intake of n‐3 PUFAs exhibited an L‐shaped relationship with asthma in children and adolescents in the United States, with a critical turning point observed at approximately 59.0 mg/kg/day.