银屑病
医学
固体脂质纳米粒
皮肤病科
纳米载体
脂质体
角质层
药理学
药品
纳米技术
材料科学
病理
作者
Sahim Aziz Hazari,Harsimran Kaur,Ritu Karwasra,Mohammed A.S. Abourehab,Asim Ali Khan,Prashant Kesharwani
标识
DOI:10.1016/j.ijpharm.2023.122938
摘要
Psoriasis is a consistently recurring, inflammatory skin disease, affecting about 2–5 % of the world population. Different types of psoriasis can be observed such as guttate psoriasis, pustular psoriasis, psoriatic arthritis, scalp psoriasis, flexural psoriasis etc. Several therapeutic approaches are available for the treatment of psoriasis. However, none of them are entirely safe and effective to treat the disease without compromising patient compliance. The traditional treatment plan is associated with harmful side effects such as immune system suppression and damage of essential organs at high doses, which poses a challenge to treat psoriasis. Novel drug delivery systems are being developed to replace traditional therapy in order to address these shortcomings. Currently, nanoformulations have gained widespread application for treatment of psoriasis. Researchers have developed different types of lipid-based nanoparticles like liposomes, niosomes, ethosomes, transethosomes, nanostructured lipid carriers and solid lipid nanoparticles. These innovative formulations provide advantages in terms of reduction in dose, dosing frequency, dose-dependency with enhanced efficacy, improved encapsulation efficiency, controlled release, increased surface area, high bioavailability and greater stratum corneum permeability. This review highlights detailed and comparative discussion of lipid-based and polymer-based nanoparticles for psoriasis along with the pathophysiology and other treatments of psoriasis.
科研通智能强力驱动
Strongly Powered by AbleSci AI