化学
表面改性
光催化
亲核细胞
激进的
发散合成
组合化学
有机合成
催化作用
路易斯酸
有机化学
锂(药物)
光化学
光催化
物理化学
内分泌学
医学
作者
Zhengbo Zhu,Siran Qian,David A. Nicewicz
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2023-01-09
卷期号:34 (09): 1023-1028
被引量:1
摘要
Direct functionalization of alkynes under oxidative conditions is challenging, as alkynes are usually recalcitrant towards typical oxidants. Herein, we communicate a strategy for the divergent functionalization of alkynes with photoexcited acridinium organic dyes, presumably via the formation of vinyl cation radicals as key intermediates. Based on the nature of the nucleophiles, different types of difunctionalized products were obtained in moderate to good yields. Addition of lithium Lewis acids resulted in a surprising reversal of diastereocontrol.
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