自愈水凝胶
伤口愈合
明胶
再生(生物学)
富血小板血浆
化学
光热治疗
生物医学工程
光热效应
肿胀 的
血管生成
皮肤修复
脚手架
纳米技术
材料科学
血小板
外科
生物化学
高分子化学
细胞生物学
癌症研究
医学
免疫学
复合材料
生物
作者
Vajihe Alinezhad,Kimia Esmaeilzadeh,Hadi Bagheri,Habib Zeighami,Ali Kalantari‐Hesari,Rahim Jafari,Pooyan Makvandi,Yi Xu,Hamidreza Mohammadi,Mohammad‐Ali Shahbazi,Aziz Maleki
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2023-01-01
卷期号:11 (17): 5872-5892
被引量:12
摘要
Wound healing remains a significant challenge worldwide, necessitating the development of new wound dressings to aid in the healing process. This study presents a novel photothermally active hydrogel that contains platelet-rich plasma (PRP) for infected wound healing. The hydrogel was formed in a one pot synthesis approach by mixing alginate (Alg), gelatin (GT), polydopamine (PDA), and PRP, followed by the addition of CaCl2 as a cross-linker to prepare a multifunctional hydrogel (AGC-PRP-PDA). The hydrogel exhibited improved strength and good swelling properties. PDA nanoparticles (NPs) within the hydrogel endowed them with high photothermal properties and excellent antibacterial and antioxidant activities. Moreover, the hydrogels sustained the release of growth factors due to their ability to protect PRP. The hydrogels also exhibited good hemocompatibility and cytocompatibility, as well as high hemostatic properties. In animal experiments, the injectable hydrogels effectively filled irregular wounds and promoted infected wound healing by accelerating re-epithelialization, facilitating collagen deposition, and enhancing angiogenesis. The study also indicated that near-infrared light improved the healing process. Overall, these hydrogels with antibacterial, antioxidant, and hemostatic properties, as well as sustained growth factor release, show significant potential for skin regeneration in full-thickness, bacteria-infected wounds.
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