In situ Generated Iridium Nanoparticles as Hydride Donors in Photoredox‐Catalyzed Hydrogen Isotope Exchange Reactions with Deuterium and Tritium Gas

Abstract We have studied the photoredox‐catalyzed hydrogen isotope exchange (HIE) reaction with deuterium or tritium gas as isotope sources and in situ formed transition metal nanoparticles as hydrogen atom transfer pre‐catalysts. By this means we have found synergistic reactivities applying two different HIE mechanisms, namely photoredox‐catalyzed and CH‐functionalization HIE leading to the synthesis of highly deuterated complex molecules. Finally, we adopted these findings successfully to tritium chemistry.