电化学发光
生物分析
生物传感器
灵敏度(控制系统)
生化工程
计算机科学
分析物
纳米技术
材料科学
化学
工程类
检出限
电子工程
色谱法
物理化学
作者
Yueyue Huang,Yuanyuan Yao,Yueliang Wang,Li‐Fen Chen,Yanbo Zeng,Hua‐Ping Peng,Longhua Guo
出处
期刊:Biosensors
[MDPI AG]
日期:2022-09-11
卷期号:12 (9): 750-750
被引量:16
摘要
Electrochemiluminescence (ECL) has received considerable attention as a powerful analytical technique for the sensitive and accurate detection of biological analytes owing to its high sensitivity and selectivity and wide dynamic range. To satisfy the growing demand for ultrasensitive analysis techniques with high efficiency and accuracy in complex real sample matrices, considerable efforts have been dedicated to developing ECL strategies to improve the sensitivity of bioanalysis. As one of the most effective approaches, diverse signal amplification strategies have been integrated with ECL biosensors to achieve desirable analytical performance. This review summarizes the recent advances in ECL biosensing based on various signal amplification strategies, including DNA-assisted amplification strategies, efficient ECL luminophores, surface-enhanced electrochemiluminescence, and ratiometric strategies. Sensitivity-enhancing strategies and bio-related applications are discussed in detail. Moreover, the future trends and challenges of ECL biosensors are discussed.
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