间充质干细胞
纤维软骨
细胞生物学
细胞外基质
再生(生物学)
细胞分化
生物
干细胞
肌腱
生长因子
脂肪生成
解剖
病理
医学
遗传学
基因
替代医学
受体
骨关节炎
关节软骨
作者
Maritha Kumlin,Karolina Lindberg,Lars-Arne Haldosén,Li Felländer‐Tsai,Yan Li
标识
DOI:10.1016/j.injury.2022.09.017
摘要
The repair of the tendon-bone interface, which is composed of tendon, fibrocartilage, and bony attachment, remains a clinical challenge. The application of mesenchymal stem cells (MSCs), collagen-rich extracellular matrix (ECMs), as well as growth factors, has the potential to regenerate this special multiple-tissue structure through the so-called biological augmentation. We present here an in vitro tendon regeneration model with C3H10T1/2 cells cultured on Collagen I matrix and evaluated the lineage determination effects of Growth Differentiation Factor 7 (GDF-7). We found that besides tenogenic effect, GDF-7 also stimulates the expression of osteoblastic as well as adipocytic genes. Our results indicate that GDF-7 might be a promising growth factor for regeneration of the tendon-bone interface due to its multiple-lineage stimulating effects. However, the side effect on adipogenic differentiation should be of concern, as it is a known risk factor for repair failures.
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