脚手架
化学
细胞生物学
间充质干细胞
信号转导
骨愈合
蛋白激酶A
运行x2
支架蛋白
磷酸化
再生(生物学)
生物医学工程
成骨细胞
解剖
生物化学
生物
体外
医学
作者
Bo Yuan,Yu-Xiang Zhang,Rui Zhao,Hai Lin,Xiao Yang,Xiangdong Zhu,Kai Zhang,Jason L. Guo,Qian Zhang
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2022-10-07
卷期号:8 (40)
被引量:21
标识
DOI:10.1126/sciadv.abq7116
摘要
Osteoinductivity of a biomaterial scaffold can notably enhance the bone healing performance. In this study, we developed a biomimetic and hierarchically porous polyetherketoneketone (PEKK) scaffold with unique osteoinductivity using a combined surface treatment strategy of a sulfonated process and a nano bone-like apatite deposition. In a beagle intramuscular model, the scaffold induced bone formation ectopically after 12-week implantation. The better bone healing ability of the scaffold than the original PEKK was also confirmed in orthotopic sites. After culturing with bone marrow-derived mesenchymal stem cells (BMSCs), the scaffold induced osteogenic differentiation of BMSCs, and the new bone formation could be mainly depending on cell signaling through adenylate cyclase 9, which activates the cyclic adenosine monophosphate/protein kinase A signaling cascade pathways. The current work reports a new osteoinductive synthetic polymeric scaffold with its detailed molecular mechanism of action for bone repair and regeneration.
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