Role of [68Ga]FAPI PET/CT in Diagnosing Thymoma and Its Implications

Abstract We report the case of a 71-year-old woman with recurrence of type B3 thymoma in which the diagnostic accuracy has benefited considerably from the additional use of [ 68 Ga]FAPI PET/CT when compared with the standard [ 18 F]FDG PET. [ 68 Ga]FAPI PET/CT confirmed the known lesions with higher lesion-to-background ratio and additionally identified a previously undetected lesion near the FDG-avid apex of the heart. This case demonstrates a potential superiority of [ 68 Ga]FAPI PET/CT in patients suffering from thymoma as detection of local recurrence close to metabolically active organs (ie, liver, heart) is improved. An improved planning of subsequent treatments (ie, lesion delineation for radiotherapy) appears possible.