Investigating the causal relationship between immune factors and ankylosing spondylitis: insights from a Mendelian Randomization study

孟德尔随机化 免疫系统 强直性脊柱炎 医学 免疫学 内科学 肿瘤科 遗传学 生物 基因 基因型 遗传变异
作者
Ziming Geng,Tong Yang,Yang Chen,Jian Wang,Ziwen Liu,Jun Miao,Ruihua Li
出处
期刊:Advances in rheumatology [BioMed Central]
卷期号:64 (1)
标识
DOI:10.1186/s42358-024-00428-1
摘要

Abstract Background Despite previous studies indicating a close relationship between immune system and ankylosing spondylitis (AS), the causal relationship between them remains unclear. Methods Genome-wide association data were utilized to explore the causal link between 731 immune cells and AS using a bidirectional two-sample MR approach. The data included immune cell data from Orrù et al.’s study and AS data from the FinnGen consortium. Cochran’s Q test and leave-one-out checked instrument variable (IV) heterogeneity. IVW was the primary method for causal analysis, with MR-Egger and MR-PRESSO addressing horizontal pleiotropy. FDR correction was applied to both analysis directions to rectify multiple testing errors. Results In our study, 22 immune phenotypes out of 731 were casually linked to AS. After excluding 5 less robust features, 17 immune factors remained, with 4 being protective and the rest posing risks. Through FDR correction, we found a significant causal relationship between HLA DR on CD14- CD16+ monocyte and AS (OR (95%CI) = 0.70(0.60 ~ 0.83), P = 2.06*10 −5 ). In the reverse analysis with AS as exposure, potential effects on 34 immune features were discovered. After correction, we confirmed significant causal relationships between AS and two immune features, namely CD20- B cell %lymphocyte (OR (95%CI) = 1.16(1.08–1.25), P = 1.91*10 −5 ) and CD20- B cell %B cell (OR (95%CI) = 1.17(1.09–1.26), P = 1.50*10 −5 ). Conclusions Our study identified various features associated with AS in different types of immune cells. These findings provide important clues and a theoretical basis for further understanding the pathogenesis of AS, guiding clinical treatment, and drug design.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
林利芳完成签到 ,获得积分0
1秒前
JaneChen完成签到 ,获得积分10
3秒前
健壮惋清完成签到 ,获得积分10
3秒前
4秒前
gabee完成签到 ,获得积分10
8秒前
liang19640908完成签到 ,获得积分10
11秒前
奋斗的雪曼完成签到 ,获得积分10
17秒前
粗心的飞槐完成签到 ,获得积分10
17秒前
LELE完成签到 ,获得积分10
24秒前
了0完成签到 ,获得积分10
25秒前
apocalypse完成签到 ,获得积分10
30秒前
guhao完成签到 ,获得积分10
31秒前
指导灰完成签到 ,获得积分10
31秒前
善良的火完成签到 ,获得积分10
42秒前
优雅夕阳完成签到 ,获得积分10
44秒前
Jasper应助光亮的自行车采纳,获得10
44秒前
miki完成签到,获得积分10
45秒前
量子星尘发布了新的文献求助10
46秒前
糖宝完成签到 ,获得积分10
53秒前
KX2024完成签到,获得积分10
56秒前
松松发布了新的文献求助20
59秒前
nusiew完成签到,获得积分10
59秒前
huiluowork完成签到 ,获得积分10
1分钟前
陶醉的翠霜完成签到 ,获得积分10
1分钟前
1分钟前
冷静如松完成签到 ,获得积分10
1分钟前
1分钟前
浮云完成签到 ,获得积分10
1分钟前
屈岂愈完成签到,获得积分10
1分钟前
1分钟前
Pupil完成签到,获得积分10
1分钟前
偏偏意气用事完成签到,获得积分10
1分钟前
安安完成签到,获得积分10
1分钟前
cttc完成签到,获得积分10
1分钟前
Chnimike完成签到 ,获得积分10
1分钟前
1分钟前
红茸茸羊完成签到 ,获得积分10
1分钟前
年轻千愁完成签到 ,获得积分10
1分钟前
liu完成签到,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038066
求助须知:如何正确求助?哪些是违规求助? 3575779
关于积分的说明 11373801
捐赠科研通 3305584
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022