Heterogeneous metabolic changes of brown and white adipose tissues are associated with metabolic adaptations in periparturient mice

白色脂肪组织 脂肪组织 褐色脂肪组织 内分泌学 怀孕 内科学 生物 胎儿 胰岛素抵抗 脂肪垫 肥胖 生理学 医学 遗传学
作者
Gang Wei,Juanjuan Zhu,Feng-jie Shen,Rongrong Xie,Chenyang Zhang,Yuan Wang,Tingting Shi,Xi Cao,Xin Ding,Jin‐Kui Yang
出处
期刊:Journal of Molecular Endocrinology [Bioscientifica]
卷期号:73 (2)
标识
DOI:10.1530/jme-24-0012
摘要

Pregnancy requires metabolic adaptations in order to meet support fetal growth with nutrient availability. In this study, the influence of pregnancy on metabolically active organs (adipose tissues in particular) was investigated. Our results showed that maternal weight and adipose mass presented dynamic remodeling in the periparturient mice. Meanwhile, pregnancy mice displayed obvious glucose intolerance and insulin resistance in late pregnancy as compared to non-pregnancy, which were partially reversed at parturition. Further analyses revealed that different fat depots exhibited site-specific adaptions of morphology and functionality as pregnancy advanced. Brown and inguinal white adipose tissue (BAT and IngWAT) exhibited obviously decreased thermogenic activity; by contrast, gonadal white adipose tissue (GonWAT) displayed remarkably increased lipid mobilization. Notably, we found that mammary gland differentiation was enhanced in IngWAT, followed by BAT but not in GonWAT. These result indicated that brown and white adipose tissues might synergistically play a crucial role in maintaining the maximum of energy supply for mother and fetus, which facilitates the mammary duct luminal epithelium development as well as the growth and development of fetus. Accompanied with adipose adaptation, however, our results revealed that the liver and pancreas also displayed significant metabolic adaptability, which together tended to trigger the risk of maternal metabolic diseases. Importantly, pregnancy-dependent obesity in our mice model resembled the disturbed metabolic phenotypes of pregnant women such as hyperglyceridemia and hypercholesterolemia. Our findings in this study could provide valuable clues for better understanding the underlying mechanisms of metabolic maladaptation and facilitate the development of the prevention and treatment of metabolic diseases.

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