上睑下垂
坏死性下垂
程序性细胞死亡
败血症
自噬
细胞
平衡
细胞生物学
生物
细胞凋亡
免疫学
医学
遗传学
生物化学
作者
Xiangli Ma,Yujie Lin,Ling Zhang,Shaoyi Miao,Haidan Zhang,Hongyao Li,Xu Fu,Li Han,P. Andy Li
标识
DOI:10.1016/j.intimp.2024.112321
摘要
Sepsis is a life-threatening multi-organ dysfunction syndrome caused by an abnormal host response to infection. Regulated cell death is essential for maintaining tissue homeostasis and eliminating damaged, infected, or aging cells in multicellular organisms. Gasdermin D, as a member of the gasdermin family, plays a crucial role in the formation of cytoplasmic membrane pores. Research has found that GSDMD plays important roles in various forms of regulated cell death such as pyroptosis, NETosis, and necroptosis. Therefore, through mediating regulated cell death, GSDMD regulates different stages of disease pathophysiology. This article mainly summarizes the concept of GSDMD, its role in regulated cell death, its involvement in organ damage associated with sepsis-related injuries mediated by regulated cell death via GSDMD activation and introduces potential drugs targeting GSDMD that may provide more effective treatment options for sepsis patients through drug modification.
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