肠道菌群
毛螺菌科
益生元
失调
拟杆菌
蔷薇花
多糖
生物
化学
微生物学
厚壁菌
生物化学
细菌
基因
遗传学
16S核糖体RNA
作者
Sijia Wang,Zixi Fu,Weibing Chen,Sitong Wu,Songze Ke,Jian‐Feng Tu,Bin Wei
标识
DOI:10.1002/cbdv.202401088
摘要
Recent studies have highlighted the potential of Saccharina japonica Polysaccharides (SJPs) in alleviating high‐fat diet (HFD)‐induced obesity by regulating gut microbiota, which warrants further exploration to elucidate the underlying structure‐activity relationship. In this study, five polysaccharide fractions (Sj‐T, Sj‐T‐1, Sj‐T‐2, Sj‐T‐3, and Sj‐T‐4) with different structure characteristics were prepared from S. japonica, and their effects on HFD‐induced obesity and gut microbiota composition were investigated using C57BL/6J mice. The results revealed that oral administration of Sj‐T considerably suppressed HFD‐induced obesity, glucose metabolic dysfunction, and other disordered symptoms. While, Sj‐T‐2, which has the lowest molecular weight, was the most effective in alleviating HFD‐induced obesity and had the second‐best effect on improving HFD‐induced impaired glucose tolerance among the five SJPs. Supplementation with SJPs significantly modulated HFD‐induced gut microbiota dysbiosis both at the phylum and species levels, such as enriching Desulfobacterota and Actinobacteriota, while suppressing the abundance of Bacteroidota. Sj‐T also dramatically restored the gut microbiota composition by modulating the abundance of many crucial gut bacterial taxa, including s_Bacteroides_acidifaciens, s_Lachnospiraceae _bacterium, and g_Lachnospiraceae_NK4A136_group. Besides, SJPs also dramatically altered the function of gut microbiota, including many carbohydrate‐metabolism enzymes. This study highlights the potential of SJPs in preventing obesity and restoring intestinal homeostasis in obese individuals.
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