苯拉唑马布
医学
安慰剂
药效学
胃肠病学
鼻息肉
嗜酸性粒细胞
药代动力学
免疫学
内科学
药理学
美波利祖马布
哮喘
病理
替代医学
作者
Claire Emson,Joseph K. Han,Nora Haloob,Sara Asimus,Jennifer Cann,David Chain,Yuling Wu,Y. Sunila Reddy,Christopher McCrae,David Cohen,James L. Kreindler,Viktoría Werkström,Maria Jison,Martin Wagenmann,Claus Bachert
摘要
Benralizumab, a humanized, afucosylated monoclonal antibody against the interleukin 5 receptor, α subunit, causes rapid depletion of eosinophils by antibody-dependent cellular cytotoxicity. We investigated the pharmacokinetic and pharmacodynamic effects of benralizumab in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) from the phase III OSTRO trial.
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