上睑下垂
活性氧
程序性细胞死亡
疾病
细胞生物学
炎症
医学
免疫学
生物
细胞凋亡
炎症体
癌症研究
病理
生物化学
作者
Jingsong Wang,Ziyong Wu,Min Zhu,Yang Zhao,Jingwen Xie
标识
DOI:10.3389/fimmu.2024.1378990
摘要
Pyroptosis, a form of caspase-1-dependent cell death, also known as inflammation-dependent death, plays a crucial role in diseases such as stroke, heart disease, or tumors. Since its elucidation, pyroptosis has attracted widespread attention from various sectors. Reactive oxygen species (ROS) can regulate numerous cellular signaling pathways. Through further research on ROS and pyroptosis, the level of ROS has been revealed to be pivotal for the occurrence of pyroptosis, establishing a close relationship between the two. This review primarily focuses on the molecular mechanisms of ROS and pyroptosis in tumors and inflammatory diseases, exploring key proteins that may serve as drug targets linking ROS and pyroptosis and emerging fields targeting pyroptosis. Additionally, the potential future development of compounds and proteins that influence ROS-regulated cell pyroptosis is anticipated, aiming to provide insights for the development of anti-tumor and anti-inflammatory drugs.
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