异恶唑
环加成
分子内力
废止
化学
炔丙基
喹唑啉
组合化学
有机化学
催化作用
作者
Zhuo Wang,Yuhan Zhao,Jiaxin Chen,Mengyao Chen,Xuehan Li,Ting Jiang,Fang Liu,Xi Yang,Yuanyuan Sun,Yanping Zhu
出处
期刊:Molecules
[MDPI AG]
日期:2023-03-20
卷期号:28 (6): 2787-2787
被引量:2
标识
DOI:10.3390/molecules28062787
摘要
A practical method was developed for the convenient synthesis of isoxazole-fused tricyclic quinazoline alkaloids. This procedure accesses diverse isoxazole-fused tricyclic quinazoline alkaloids and their derivatives via intramolecular cycloaddition of methyl azaarenes with tert-butyl nitrite (TBN). In this method, TBN acts as the radical initiator and the source of N-O. Moreover, this protocol forms new C-N, C-C, and C-O bonds via sequence nitration and annulation in a one-pot process with broad substrate scope and functionalization of natural products.
科研通智能强力驱动
Strongly Powered by AbleSci AI