纳米颗粒
化学工程
硫酸软骨素
降水
粒径
热稳定性
化学
共沉淀
浊度
材料科学
色谱法
生物化学
海洋学
物理
地质学
工程类
糖胺聚糖
气象学
作者
Yue Zhuo,Yuehui Liang,Duoxia Xu,David Julian McClements,Suqing Wang,Qi Li,Yahong Han,Fuguo Liu,Shuai Chen
标识
DOI:10.1016/j.ijbiomac.2023.125109
摘要
Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles with different compositions were successfully fabricated using a novel antisolvent co-precipitation method. The mean particle diameter (97.5 to 219.4 nm), negative surface potential (-29.9 to -51.1 mV), and turbidity (265 to 370 NTU) of suspensions of Zein-Que nanoparticles increased after the addition of CS. Electrostatic attraction, hydrogen bonding, and hydrophobic attraction were the main driving forces for the formation of the composite nanoparticles. The encapsulation efficiency and loading capacity of the quercetagetin within the Zein-Que-CS (100:10:30) nanoparticles were 91.6 % and 6.1 %, respectively. The photostability and thermal stability of the encapsulated quercetagetin were 3.4- and 3.2- fold higher than that of the free form. The nanoparticles had good resistance to sedimentation and exhibited slow-release properties under simulated gastrointestinal conditions. The Zein-Que-CS nanoparticles developed in this study may therefore be useful for the encapsulation, protection, and delivery of quercetagetin.
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