生物
DNA修复
DNA
核苷酸切除修复
遗传学
基因
DNA损伤
抄写(语言学)
基底切除修复术
细胞生物学
DNA错配修复
语言学
哲学
作者
Shalini Guha,Sukesh R. Bhaumik
出处
期刊:DNA Repair
[Elsevier]
日期:2022-01-01
卷期号:109: 103211-103211
被引量:20
标识
DOI:10.1016/j.dnarep.2021.103211
摘要
The genomic DNA is constantly under attack by cellular and/or environmental factors. Fortunately, the cell is armed to safeguard its genome by various mechanisms such as nucleotide excision, base excision, mismatch and DNA double-strand break repairs. While these processes maintain the integrity of the genome throughout, DNA repair occurs preferentially faster at the transcriptionally active genes. Such transcription-coupled repair phenomenon plays important roles to maintain active genome integrity, failure of which would interfere with transcription, leading to an altered gene expression (and hence cellular pathologies/diseases). Among the various DNA damages, DNA double-strand breaks are quite toxic to the cells. If DNA double-strand break occurs at the active gene, it would interfere with transcription/gene expression, thus threatening cellular viability. Such DNA double-strand breaks are found to be repaired faster at the active gene in comparison to its inactive state or the inactive gene, thus supporting the existence of a new phenomenon of transcription-coupled DNA double-strand break repair. Here, we describe the advances of this repair process.
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