Polycystic ovarian syndrome (PCOS) is the most common endocrine condition in women, affecting anywhere from 3% to 13% depending on the population being studied. PCOS often begins in adolescence, but diagnosis is difficult due to the overlap of symptoms with normal puberty. It is also necessary to rule out other potential causes of these symptoms before diagnosis. Once diagnostic criteria have been met, there are many treatment options to consider including lifestyle changes, combined oral contraceptive pills, metformin, and in some cases, antiandrogens. [Pediatr Ann. 2021;50(7):e272-e275.].