微生物群
肠道菌群
肠道微生物群
胰岛素抵抗
医学
糖尿病
生物信息学
免疫学
炎症
临床试验
失调
生物
内分泌学
作者
Wei Ling Lau,Tiffany Tran,Connie M. Rhee,Kamyar Kalantar‐Zadeh,Nosratola D. Vaziri
标识
DOI:10.1016/j.semnephrol.2021.03.005
摘要
Gut dysbiosis in diabetes mellitus is associated with decreased short-chain fatty acids and epithelial barrier disruption. Microbial-derived toxins move across the "leaky gut" and incur systemic inflammation and insulin resistance. In children, gut dysbiosis has been associated with risk of developing type 1 diabetes mellitus. In animal models, the obesity phenotype is transferable via microbiota transplantation. Plant-based low protein diets and certain anti-diabetic drugs have been associated with positive microbiome effects. Clinical trials with prebiotics and probiotics have yielded mixed results. Further investigations are needed to evaluate the gut microbiome as a potential therapeutic target for diabetes prevention and management.
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