生物
疾病
功能(生物学)
先天免疫系统
内生
机制(生物学)
炎症
免疫系统
细胞生物学
免疫学
病理
医学
认识论
内分泌学
哲学
作者
Karl N. Miller,Stella Victorelli,Hanna Salmonowicz,Nirmalya Dasgupta,Tianhui Liu,João F. Passos,Peter D. Adams
出处
期刊:Cell
[Elsevier]
日期:2021-10-01
卷期号:184 (22): 5506-5526
被引量:125
标识
DOI:10.1016/j.cell.2021.09.034
摘要
Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of inflammation in diverse physiological and pathological contexts. Although the role of endogenous cytoDNA in innate immune activation is well established, the cytoDNA species themselves are often poorly characterized and difficult to distinguish, and their mechanisms of formation, scope of function and contribution to disease are incompletely understood. Here, we summarize current knowledge in this rapidly progressing field with emphases on similarities and differences between distinct cytoDNAs, their underlying molecular mechanisms of formation and function, interactions between cytoDNA pathways, and therapeutic opportunities in the treatment of age-associated diseases.
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