溶癌病毒
溶瘤病毒
临床试验
医学
免疫疗法
放射治疗
癌症
癌症治疗
化疗
癌症治疗
肿瘤科
免疫学
病毒学
内科学
作者
Weijian Lin,Yongxiang Zhao,Liping Zhong
摘要
As a novel immune-active agent for cancer treatment, viruses have the ability of infecting and replicating in tumor cells. The safety and efficacy of viruses has been tested and confirmed in preclinical and clinical trials. In the last decade, virotherapy has been adopted as a monotherapy or combined therapy with immunotherapy, chemotherapy, or radiotherapy, showing promising outcomes against cancer. In this review, the current strategies of viruses used in clinical trials are classified and described. Besides this, the challenge and future prospects of virotherapy in the management for cancer patients are discussed in this review.
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