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[Study on the relationship between ultrasonographic features of papillary thyroid carcinoma and central cervical lymph node metastasis].

医学 甲状腺癌 转移 放射科 甲状腺乳突癌 淋巴结 钙化 单变量分析 病理 甲状腺 癌症 内科学 多元分析
作者
Xiaoqing Wang,Wei Wei,Xi Wang,Yong Xu,Hai‐Ling Wang,Xin Xing,Sheng Zhang
出处
期刊:PubMed 卷期号:40 (3): 196-200 被引量:11
标识
DOI:10.3760/cma.j.issn.0253-3766.2018.03.007
摘要

Objective: To investigate the correlation between ultrasonographic features of papillary thyroid carcinoma and central cervical lymph node metastasis. Methods: We retrospectively analyzed 486 patients with papillary thyroid carcinoma(PTC), pathologically confirmed after surgery in Tianjin Medical University Cancer Institute & Hospital. All patients were divided into central cervical lymph node metastasis group and non-metastasis group. No lateral cervical lymph node metastasis was found in preoperative ultrasonography and postoperative pathology. The characteristics of the ultrasound was observed and analyzed. Results: 297 out of 486 patients with papillary thyroid carcinomahad central metastasis, and the other 189 cases did not. Take pathology results as a standard, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate of preoperative ultrasound diagnosis in PTC patients with central cervical lymph node metastasis were 35.3%, 88.6%, 83.2%, 47.4%, 56.6%, respectively. Univariate analysis showed that multi-focus, taller-than-wide, diameter>1 cm, located in the lower pole, ill-defined margin, hypoechogenicity, micro-calcification, capsule invasion more than 1/4 perimeter of papillary thyroid carcinoma were significantly associated with central cervical lymph node metastasis (all P<0.05). Multivariate analysis showed that diameter>1 cm, micro-calcification, capsule invasion more than 1/4 perimeter of papillary thyroid carcinoma became independent risk factors of central cervical neck lymph node metastasis (all P<0.05). Conclusions: Preoperative description of ultrasonographical features has important value to assess central cervical lymph node metastasis in patients with papillary thyroid carcinoma. More information could be provided for clinical treatment. When the papillary thyroid carcinoma presented as diameter>1 cm, micro-calcification, and capsule invasion more than 1/4 perimeter of, there will be a greater risk of central cervical lymph node metastasis, and we shall suggest prophylactic central lymph cervical node dissection.目的: 探讨甲状腺乳头状癌(PTC)的超声征象与颈部中央区淋巴结转移的关系。 方法: 回顾性分析在天津医科大学肿瘤医院手术且经病理证实的486例PTC患者的临床资料,将患者分为颈部中央区淋巴结转移组和无转移组,所有患者术前超声和术后病理均无侧颈部淋巴结转移,观察原发癌的超声特征,对其进行统计学分析。 结果: 486例PTC患者中,中央区有转移297例,无转移189例。以病理结果为标准,术前超声诊断PTC患者颈部中央区淋巴结转移的敏感度、特异度、阳性预测值、阴性预测值和准确率分别为35.3%、88.6%、83.2%、47.4%和56.6%。单因素分析结果显示,PTC多灶、纵横比≥1、直径>1 cm、位于下极、边界不清、低回声、微小钙化、被膜侵及的长度/结节周长≥1/4的患者易发生颈部中央区淋巴结转移(均P<0.05)。多因素分析结果显示,PTC肿瘤直径>1 cm、微小钙化、被膜侵及的长度/结节周长≥1/4是颈部中央区淋巴结转移的独立危险因素(均P<0.05)。 结论: 术前描述PTC的超声征象对提示颈部中央区淋巴结转移具有重要价值,可为临床治疗提供更多信息。当PTC直径>1 cm、微小钙化、被膜侵及的长度/结节周长≥1/4时,伴颈部中央区淋巴结转移的风险较大,建议行预防性中央区淋巴结清扫。.
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