No independent or combined effects of vitamin D and conjugated linoleic acids on muscle protein synthesis in older adults: a randomized, double-blind, placebo-controlled clinical trial

共轭亚油酸 合成代谢 内科学 内分泌学 安慰剂 维生素 肌原纤维 化学 维生素D与神经学 亚油酸 医学 生物化学 脂肪酸 替代医学 病理
作者
Stephan van Vliet,Alan Fappi,Dominic N. Reeds,Bettina Mittendorfer
出处
期刊:The American Journal of Clinical Nutrition [Elsevier BV]
卷期号:112 (5): 1382-1389 被引量:19
标识
DOI:10.1093/ajcn/nqaa240
摘要

Aging is associated with skeletal muscle anabolic resistance (i.e., reduced muscle protein synthesis during anabolic conditions such as hyperaminoacidemia). The results from studies conducted in cell culture systems and animals suggest that both vitamin D and conjugated linoleic acids (CLAs) stimulate muscle protein synthesis. To conduct a randomized, double-blind, placebo-controlled clinical trial to determine the independent and combined effects of dietary vitamin D and CLA supplementation on myofibrillar protein synthesis rates in sedentary older adults. Thirty-two sedentary, older adults were randomized to receive either: 1) 2000 IU vitamin D-3 (Vit D) per day; 2) 4000 mg CLA per day; 3) both Vit D (2000 IU/d) and CLA (4000 mg/d); or 4) placebo for 8 wk. Myofibrillar protein synthesis rates were evaluated by using intravenous [ring-2H5]phenylalanine infusion in conjunction with muscle biopsies during basal, postabsorptive conditions and during combined amino acid and insulin infusion before and after the supplementation period. Before the intervention, basal myofibrillar protein synthesis rates were not different among groups (Placebo: 0.033 ± 0.003; Vit D: 0.034 ± 0.002; CLA: 0.029 ± 0.005; Vit D + CLA: 0.038 ± 0.005 %·h-1), and hyperinsulinemia–hyperaminoacidemia increased myofibrillar protein synthesis rates by ∼35%. Compared with placebo, neither Vit D nor CLA nor combined Vit D + CLA supplementation affected the basal myofibrillar protein synthesis rates (placebo: 0.040 ± 0.004%/h; Vit D: 0.044 ± 0.006%/h; CLA: 0.039 ± 0.006%/h; Vit D + CLA: 0.040 ± 0.007%/h) or the hyperinsulinemia–hyperaminoacidemia–induced increase in myofibrillar protein synthesis (percentage increase from basal before and after the interventions: placebo, 30 ± 11 and 36 ± 11; Vit D, 38 ± 8 and 34 ± 10; CLA, 50 ± 14 and 51 ± 16; Vit D + CLA, 29 ± 15 and 35 ± 8). Vitamin D and/or CLA supplementation, at the doses provided in our study, does not have muscle anabolic effects in sedentary older adults. The study was registered at clinicaltrials.gov (NCT03115775).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
ZDY完成签到,获得积分10
1秒前
标致醉波完成签到,获得积分10
1秒前
1秒前
111完成签到,获得积分10
1秒前
2秒前
bkagyin应助yunsww采纳,获得10
2秒前
小蜜蜂完成签到,获得积分10
2秒前
2秒前
li发布了新的文献求助10
3秒前
茗姜发布了新的文献求助60
3秒前
朴实的草丛完成签到 ,获得积分10
3秒前
张洁纯发布了新的文献求助30
3秒前
3秒前
徐一一发布了新的文献求助10
3秒前
bkagyin应助淡定的鸭子采纳,获得10
3秒前
牟弼完成签到,获得积分10
3秒前
4秒前
4秒前
go完成签到,获得积分10
4秒前
YY完成签到,获得积分10
4秒前
干净怀寒发布了新的文献求助10
5秒前
CipherSage应助凸迩丝儿采纳,获得10
5秒前
cannice完成签到,获得积分10
5秒前
远不止这些完成签到,获得积分10
5秒前
5秒前
飞云发布了新的文献求助10
6秒前
lin完成签到,获得积分10
6秒前
卫川影发布了新的文献求助10
6秒前
楼山柳完成签到,获得积分10
6秒前
Ilan发布了新的文献求助10
6秒前
6秒前
乐乐应助pendulum采纳,获得30
7秒前
GJL发布了新的文献求助10
7秒前
7秒前
饱满从露发布了新的文献求助10
7秒前
njc大魔王完成签到,获得积分10
8秒前
8秒前
WY发布了新的文献求助10
8秒前
9秒前
愿景完成签到,获得积分10
9秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969322
求助须知:如何正确求助?哪些是违规求助? 3514152
关于积分的说明 11172188
捐赠科研通 3249407
什么是DOI,文献DOI怎么找? 1794832
邀请新用户注册赠送积分活动 875437
科研通“疑难数据库(出版商)”最低求助积分说明 804781