Role of ANXA1, IL15, PERK, INSIG1 genes and endoplasmic reticulum stress in foam cell formation

Background and Aims: Endoplasmic reticulum (ER) stress disturbs cholesterol metabolism in human cells by impairing cholesterol efflux, influx, and synthesis. Cholesterol loading of human monocyte-derived macrophages (MDM) by LDL resulted in increased ANXA1, CXCL8, IL-15, and PERK mRNA expressions. Incubation of MDM with HDL, in turn, led to increased INSIG1 mRNA expression. In this study, our aim was to evaluate the role of ANXA1, IL15, PERK, CXCL8, INSIG1 genes in cholesterol metabolism.