自身抗体
内科学
内分泌学
受体
医学
淋巴细胞
CD8型
心功能曲线
脾脏
抗体
免疫学
免疫系统
心力衰竭
作者
Li Y,Jianwei Tian,Ma Xr,Li Rt,Zhang Sl,Wang Pl,Yin Xc,Bian Jw,Lei Jh,Liu Hr
出处
期刊:PubMed
日期:2017-03-01
卷期号:21 (5): 1065-1073
被引量:5
摘要
This study aimed to explore the effects of diet-induced hypercholesterolemia (HC) on the production of G protein-coupled receptor autoantibodies and to elucidate the potential mechanisms involved.Male Wistar rats were fed a normal or high-cholesterol diet for 8 weeks. Cardiac function, autoantibodies against G protein-coupled receptors, the beat frequency of neonatal cardiomyocytes, the CD4+/CD8+ T-lymphocyte ratio and lymph leukocyte counts in the spleen were determined.Diet-induced hypercholesterolemia significantly increased the levels of autoantibodies against α1- and β1-adrenergic receptors and the angiotensin II type 1 receptor in sera, as well as the CD4+/CD8+ T-lymphocyte ratio and lymph leukocyte count in the spleen, and decreased cardiac function. There were strong negative correlations between the levels of autoantibodies and cardiac injury.The present study demonstrates, for the first time, that G protein-coupled receptor autoantibodies exist in the sera of hypercholesterolemic rats and that the levels of these autoantibodies are related to cardiac function, which implies that these cardiac receptor autoantibodies may play a role in cardiac dysfunction in hypercholesterolemic rats.
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