Hereditary angioedema: Epidemiology and burden of disease

医学遗传性血管水肿血管性水肿呈现主义焦虑旷工疾病生活质量（医疗保健）萧条（经济学）内科学皮肤病科精神科宏观经济学护理部经济管理

作者

William R. Lumry,Russell A. Settipane

出处

期刊：Allergy and Asthma Proceedings [OceanSide Publications, Inc]
日期：2020-10-28 卷期号：41 (6): S08-S13 被引量：92

链接

nih.govdoi.org

标识

DOI：10.2500/aap.2020.41.200050

摘要

Hereditary angioedema (HAE) is a rare autosomal dominant genetic disorder characterized by swelling of subcutaneous, mucosal, and submucosal tissue without associated pruritus or wheals caused by a temporary localized increase in vascular permeability. Swelling attacks primarily affect the cutaneous tissue, abdominal viscera, genitals, or airways. <title/> Reports of the prevalence of HAE C1 inhibitor (C1-INH) deficiency varies widely, from 1:50,000 to 1:100,000. The prevalence of HAE normal C1-INH is unknown but is likely much lower than HAE C1-INH. Approximately one-third of patients with recurrent angioedema without wheals have HAE. <title/> The burden of disease for patients with HAE is substantial. Attacks are unpredictable with respect to frequency, severity, and the site that swells. Laryngeal attacks can be fatal if not treated promptly and appropriately. Feelings of stress, anxiety, and depression can trigger attacks, and begin a cycle of attacks that cause anxiety that, in turn, triggers further attacks. Despite full physical recovery between attacks, patients often experience continual emotional impairment and reduced quality of life (QoL). Absenteeism from work and presenteeism at work or educational activities for patients and caregivers increase stress and reduce productivity during and between attacks. 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</dd> <dd id="1744336824741"> <div class="sign"><i class="layui-icon iconfont-ex icon-ex-qiandao2"></i> <a class="badge name" href="/user/home?id=LN2PmW">野性的尔琴</a>完成签到，获得积分<span class="point"><i class="layui-icon iconfont-ex icon-ex-jifen"></i>10</span></div> <div>6秒前</div> </dd> <dd id="1744336824121"> <div><a class="badge name" href="/user/home?id=851g5M">领导范儿</a>的<a class="badge assist" href="/assist/detail?id=OdG6z0#assist-timeline">应助</a>被<a class="badge name" href="/user/home?id=nP2y9e">犹豫嚣</a>采纳，获得<span class="point"><i class="layui-icon iconfont-ex icon-ex-jifen"></i>10</span></div> <div>6秒前</div> </dd> <dd id="1744336824775"> <div class="sign"><i class="layui-icon iconfont-ex icon-ex-qiandao2"></i> <a class="badge name" href="/user/home?id=8KvNPZ">阳佟半仙</a>完成签到，获得积分<span class="point"><i class="layui-icon iconfont-ex icon-ex-jifen"></i>10</span></div> <div>6秒前</div> </dd> <dd id="1744336823405"> <div class="sign"><i class="layui-icon iconfont-ex icon-ex-qiandao2"></i> <a class="badge name" href="/user/home?id=Z6kYkB">疯了半天</a>完成签到，获得积分<span class="point"><i class="layui-icon iconfont-ex icon-ex-jifen"></i>10</span></div> <div>7秒前</div> </dd> <dd id="1744336823487"> <div class="sign"><i class="layui-icon iconfont-ex icon-ex-qiandao2"></i> <a class="badge name" href="/user/home?id=nPGzza">高高</a>完成签到 <i title="微信签到" class="layui-icon layui-icon-login-wechat"></i>，获得积分<span class="point"><i class="layui-icon iconfont-ex icon-ex-jifen"></i>10</span></div> <div>7秒前</div> </dd> <dd id="1744336823472"> <div><a class="badge name" href="/user/home?id=ZbKj94">传奇3</a>的<a class="badge assist" href="/assist/detail?id=P8zDGj#assist-timeline">应助</a>被<a class="badge name" href="/user/home?id=853DdY">邓娇叶</a>采纳，获得<span class="point"><i class="layui-icon iconfont-ex icon-ex-jifen"></i>10</span></div> <div>7秒前</div> </dd> <dd id="1744336823928"> <div><a class="badge name" href="/user/home?id=nParVZ">tree薯要吃麦麦</a>发布了新的<a class="badge assist" href="/assist/detail?id=yMPM7r">文献求助</a><span class="point"><i class="layui-icon iconfont-ex icon-ex-jifen"></i>10</span></div> <div>7秒前</div> </dd> <dd id="1744336822760"> <div><a class="badge name" href="/user/home?id=LpQGz2">京阿尼</a>发布了新的<a class="badge assist" href="/assist/detail?id=ekRk4y">文献求助</a><span class="point"><i class="layui-icon iconfont-ex icon-ex-jifen"></i>10</span></div> <div>8秒前</div> </dd> <dd id="1744336821198"> <div><a class="badge name" href="/user/home?id=ZzoAd8">天天快乐</a>上传了<a class="badge assist" href="/assist/detail?id=M4p4A9">应助文件</a></div> <div>9秒前</div> </dd> <dd id="1744336820650"> <div><a class="badge name" href="/user/home?id=8ykk23">cdercder</a>的<a class="badge assist" href="/assist/detail?id=55D5yy#assist-timeline">应助</a>被<a class="badge name" href="/user/home?id=LkY5mo">Ziwei</a>采纳，获得<span class="point"><i class="layui-icon iconfont-ex icon-ex-jifen"></i>20</span></div> <div>10秒前</div> </dd> <dd id="1744336819359"> <div><a class="badge name" href="/user/home?id=LpA37p">可爱丹烟</a>发布了新的<a class="badge assist" href="/assist/detail?id=j8p8M6">文献求助</a><span class="point"><i class="layui-icon iconfont-ex icon-ex-jifen"></i>30</span></div> <div>11秒前</div> </dd> <dd id="1744336819653"> <div class="sign"><i class="layui-icon iconfont-ex icon-ex-qiandao2"></i> <a class="badge name" href="/user/home?id=LXlEkg">wudayong</a>完成签到，获得积分<span class="point"><i class="layui-icon iconfont-ex icon-ex-jifen"></i>10</span></div> <div>11秒前</div> </dd> <dd id="1744336819281"> <div class="sign"><i class="layui-icon iconfont-ex icon-ex-qiandao2"></i> <a class="badge name" href="/user/home?id=85y4VM">松鼠非鼠</a>完成签到，获得积分<span class="point"><i class="layui-icon iconfont-ex icon-ex-jifen"></i>10</span></div> <div>11秒前</div> </dd> </div> </dl> <dl class="fly-panel fly-list-one hot-assist"> <dt class="fly-panel-title">高分求助中 <i class="layui-icon layui-icon-fire"></i></dt> <dd> <a target="_blank" href="https://www.ablesci.com/assist/detail?id=4EX71z">Seven new species of the Palaearctic Lauxaniidae and Asteiidae (Diptera)</a> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>400</span> </dd> <dd> <a target="_blank" href="https://www.ablesci.com/assist/detail?id=wB6aPd">Where and how to use plate heat exchangers</a> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>350</span> </dd> <dd> <a target="_blank" href="https://www.ablesci.com/assist/detail?id=6dXwJZ">Handbook of Laboratory Animal Science</a> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>300</span> </dd> <dd> <a target="_blank" href="https://www.ablesci.com/assist/detail?id=K1Ob0p">Fundamentals of Medical Device Regulations, Fifth Edition(e-book)</a> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>300</span> </dd> <dd> <a target="_blank" href="https://www.ablesci.com/assist/detail?id=OdGbo6">Beginners Guide To Clinical Medicine (Pb 2020): A Systematic Guide To Clinical Medicine, Two-Vol Set</a> <span><i class="layui-icon iconfont-ex 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layui-badge-rim">生物</span> <span title="Engineering 热度：★★" class="hot-fields-item layui-badge-rim">工程类</span> <span title="Organic chemistry 热度：★★" class="hot-fields-item layui-badge-rim">有机化学</span> <span title="Physics 热度：★" class="hot-fields-item layui-badge-rim">物理</span> <span title="Biochemistry 热度：★" class="hot-fields-item layui-badge-rim">生物化学</span> <span title="Nanotechnology 热度：★" class="hot-fields-item layui-badge-rim">纳米技术</span> <span title="Computer science 热度：★" class="hot-fields-item layui-badge-rim">计算机科学</span> <span title="Chemical engineering 热度：★" class="hot-fields-item layui-badge-rim">化学工程</span> <span title="Internal medicine 热度：★" class="hot-fields-item layui-badge-rim">内科学</span> <span title="Composite material 热度：★" class="hot-fields-item layui-badge-rim">复合材料</span> <span title="Physical chemistry 热度：★" class="hot-fields-item layui-badge-rim">物理化学</span> <span title="Electrode 热度：★" class="hot-fields-item layui-badge-rim">电极</span> <span title="Genetics 热度：★" class="hot-fields-item layui-badge-rim">遗传学</span> <span title="Quantum mechanics 热度：★" class="hot-fields-item layui-badge-rim">量子力学</span> <span title="Gene 热度：★" class="hot-fields-item layui-badge-rim">基因</span> <span title="Metallurgy 热度：★" class="hot-fields-item layui-badge-rim">冶金</span> <span title="Catalysis 热度：★" class="hot-fields-item layui-badge-rim">催化作用</span> </div> </dl> <dl class="fly-panel fly-list-one hot-post"> <dt class="fly-panel-title">热门帖子 <i class="layui-icon layui-icon-dialogue"></i></dt> <dd> <a title="点击查看" href="https://www.ablesci.com/post/detail?id=9VPm4b" target="_blank"><span style="color:#00F; font-weight:bold; font-size: 14px;"> 关注 <i style="color:#07C160;" class="layui-icon layui-icon-login-wechat"></i> 科研通微信公众号，转发送积分 <i class="layui-icon iconfont-ex icon-ex-jifen"></i></span></a> <span><i class="layui-icon iconfont-ex icon-ex-eye"></i> 3705543</span> </dd> <dd> <a title="点击查看" href="https://www.ablesci.com/post/detail?id=Pb63Qj" target="_blank"><span style="color:#F00; font-weight:bold; font-size: 14px;">求助须知：如何正确求助？哪些是违规求助？</span></a> <span><i class="layui-icon iconfont-ex icon-ex-eye"></i> 3254750</span> </dd> <dd> <a title="点击查看" href="https://www.ablesci.com/post/detail?id=NQKd7P" target="_blank"><font style="color:#c021df; font-weight:bold;font-size:18px !important">关于积分的说明</font></a> <span><i class="layui-icon iconfont-ex icon-ex-eye"></i> 9891243</span> </dd> <dd> <a title="点击查看" href="https://www.ablesci.com/post/detail?id=P7j5Qn" target="_blank"><font style="color:#00f; font-weight:bold;font-size:16px !important">捐赠科研通</font></a> <span><i class="layui-icon iconfont-ex icon-ex-eye"></i> 2966732</span> </dd> <dd> <a title="点击查看" href="https://www.ablesci.com/post/detail?id=9VP4Vw" target="_blank">什么是DOI，文献DOI怎么找？</a> <span><i class="layui-icon iconfont-ex icon-ex-eye"></i> 1627103</span> </dd> <dd> <a title="点击查看" href="https://www.ablesci.com/post/detail?id=Q9jRn7" target="_blank"><font style="color:#c021df; font-weight:bold;font-size:16px !important">邀请新用户注册赠送积分活动</font></a> <span><i class="layui-icon iconfont-ex icon-ex-eye"></i> 771241</span> </dd> <dd> <a title="点击查看" href="https://www.ablesci.com/post/detail?id=1VrznV" target="_blank"><font style="color:#00f; font-weight:bold;">科研通“疑难数据库（出版商）”最低求助积分说明</font></a> <span><i class="layui-icon iconfont-ex icon-ex-eye"></i> 743251</span> </dd> </dl> <div class="fly-panel fly-rank fly-rank-reply hot-assisters" id="LAY_replyRank"> <h3 class="fly-panel-title"> <a href="javascript:void(0);" class="layui-this hot-today" title="自今天零点开始">今日热心研友</a> <span title="查看说明" href="javascript:void(0);" class="rank-tips" style="cursor: pointer"><i class="layui-icon layui-icon-about"></i></span> </h3> <div class="hot-assisters-item hot-assisters-today"> <dl>  <dd > <a href="https://www.ablesci.com/user/home?id=Z6kJwm" target="_blank" title="当前排名第 1 今日热心度 95 　- 参与应助 60 次　- 获得积分 350"> <img src="https://staticres.ablesci.com/avatar/sys/v1/2j3Oq_05D3.png?v=RM3QXpOv"> <cite >iNk</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon layui-icon-fire"></i>60</span> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>350</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=Z7X20M" target="_blank" title="当前排名第 2 今日热心度 90 　- 参与应助 48 次　- 获得积分 420"> <img src="https://staticres.ablesci.com/avatar/u/d5e13c0a38ad89b2d459415b2d9fefb9.jpg?v=1lvdbDxjjn"> <cite >斯寜</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon layui-icon-fire"></i>48</span> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>420</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=LMrjP0" target="_blank" title="当前排名第 3 今日热心度 90 　- 参与应助 31 次　- 获得积分 590"> <img src="https://staticres.ablesci.com/avatar/u/c7f1df319fffb6eb8e4cddc9f933e91b.png"> <cite >back you up</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon layui-icon-fire"></i>31</span> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>590</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=LXj4PR" target="_blank" title="当前排名第 4 今日热心度 66 　- 参与应助 0 次　- 获得积分 666"> <img src="https://staticres.ablesci.com/avatar/sys/v1/ZW4jw_05CZ.png?v=ZvJlL43a"> <cite >Hayat</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>666</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=LkWOl9" target="_blank" title="当前排名第 5 今日热心度 66 　- 参与应助 0 次　- 获得积分 660"> <img src="https://staticres.ablesci.com/avatar/sys/v1/q9nLG_0Q9P.png?v=xmJDebrr"> <cite >nozero</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>660</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=8yXYgq" target="_blank" title="当前排名第 6 今日热心度 65 　- 参与应助 35 次　- 获得积分 300"> <img src="https://staticres.ablesci.com/avatar/sys/v1/wB7Dn_0294.png?v=xoJykAG6"> <cite >HEIKU</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon layui-icon-fire"></i>35</span> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>300</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=8yk6wO" target="_blank" title="当前排名第 7 今日热心度 63 　- 参与应助 23 次　- 获得积分 400"> <img src="https://staticres.ablesci.com/avatar/sys/v1/25JrO_0DLL.png?v=EKO3kJz1"> <cite >小透明</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon layui-icon-fire"></i>23</span> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>400</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=8ykk23" target="_blank" title="当前排名第 8 今日热心度 56 　- 参与应助 23 次　- 获得积分 330"> <img src="https://staticres.ablesci.com/avatar/u/7ebabaea87e3f3dd1f41850afb27537e.jpeg?v=zl0ZvKaX7n"> <cite >cdercder</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon layui-icon-fire"></i>23</span> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>330</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=Lme4VQ" target="_blank" title="当前排名第 9 今日热心度 50 　- 参与应助 0 次　- 获得积分 500"> <img src="https://staticres.ablesci.com/avatar/sys/v1/wBnvp_0I4D.png?v=xVk3DL5L"> <cite >迷人秋烟</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>500</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=Z74ADM" target="_blank" title="当前排名第 10 今日热心度 47 　- 参与应助 0 次　- 获得积分 470"> <img src="https://staticres.ablesci.com/avatar/sys/v1/2RAWQ_0NWA.png?v=E9PdWak3"> <cite >bc</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>470</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=aLj128" target="_blank" title="当前排名第 11 今日热心度 40 　- 参与应助 0 次　- 获得积分 400"> <img src="https://staticres.ablesci.com/avatar/u/c7cb075724b1cc1a90ef7c2a00d04b25.png?v=JADZ3K7Wwr"> <cite >科研小民工</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>400</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=nVPJKk" target="_blank" title="当前排名第 12 今日热心度 40 　- 参与应助 40 次　- 获得积分 0"> <img src="https://staticres.ablesci.com/avatar/sys/v1/wNeDa_0FVV.png?v=RqJe9wmw"> <cite >大方汉堡</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon layui-icon-fire"></i>40</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=Z616OD" target="_blank" title="当前排名第 13 今日热心度 38 　- 参与应助 15 次　- 获得积分 230"> <img src="https://staticres.ablesci.com/avatar/sys/v1/2vV7E_0HIX.png?v=x3Aj87qp"> <cite >mingpu</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon layui-icon-fire"></i>15</span> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>230</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=8Dwyo3" target="_blank" title="当前排名第 14 今日热心度 25 　- 参与应助 0 次　- 获得积分 250"> <img src="https://staticres.ablesci.com/avatar/sys/v1/wpbvL_0AEK.png?v=RP5rW70k"> <cite >自然的诗翠</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>250</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=853b0p" target="_blank" title="当前排名第 15 今日热心度 24 　- 参与应助 24 次　- 获得积分 0"> <img src="https://staticres.ablesci.com/avatar/sys/v1/wNkyM_0ALY.png?v=E9PDb5e5"> <cite >Xiaoxiao</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon layui-icon-fire"></i>24</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=LNg0bW" target="_blank" title="当前排名第 16 今日热心度 24 　- 参与应助 24 次　- 获得积分 0"> <img src="https://staticres.ablesci.com/avatar/sys/v1/qe9m6_03F8.png?v=ZrmWokww"> <cite >无曲</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon layui-icon-fire"></i>24</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=8WzmvP" target="_blank" title="当前排名第 17 今日热心度 23 　- 参与应助 23 次　- 获得积分 0"> <img src="https://staticres.ablesci.com/avatar/u/4e2c49fd1dc89d45196ada20014eff61.png?v=12ff"> <cite >Lj</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon layui-icon-fire"></i>23</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=Z74bX2" target="_blank" title="当前排名第 18 今日热心度 23 　- 参与应助 23 次　- 获得积分 0"> <img src="https://staticres.ablesci.com/avatar/u/827b36fc139163e0a27f80e8c4ea7916.jpg?v=ElRKP37KjA"> <cite >椰子在长江送礼物</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon layui-icon-fire"></i>23</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=LJb6Y2" target="_blank" title="当前排名第 19 今日热心度 22 　- 参与应助 22 次　- 获得积分 0"> <img src="https://staticres.ablesci.com/avatar/sys/v1/2EJ5e_04BA.png?v=R1AN4dYD"> <cite >CHEN</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon layui-icon-fire"></i>22</span> </div> </a> </dd> <dd > <a href="https://www.ablesci.com/user/home?id=nqw9ra" target="_blank" title="当前排名第 20 今日热心度 21 　- 参与应助 0 次　- 获得积分 210"> <img src="https://staticres.ablesci.com/avatar/sys/v1/2oMJz_0RZG.png?v=RM3we1gJ"> <cite >勿明</cite>   <div class="user-count-content" style=" margin-left: -10px; margin-right: -10px; color: #666; height: 15px; line-height: 15px; overflow: hidden"> <span><i class="layui-icon iconfont-ex icon-ex-jifen"></i>210</span> </div> </a> </dd> </dl> <div style="margin-top:5px;font-size: 12px; padding-left: 20px; color: #999; ">注：热心度 = 本日应助数 + 本日被采纳获取积分÷10</div> </div> </div> <script> layui.use(['jquery','layer'], function() { var $ = layui.jquery, layer = layui.layer; $('.hot-assisters-tips').bind('click', function(){ layer.tips('每30分钟更新一次', this, { tips: 3 }); }); $('.rank-tips').bind('click', function(){ var 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