生物
抗生素耐药性
适应(眼睛)
抗性(生态学)
意外事故
遗传学
实验进化
谱系(遗传)
进化生物学
作者
Kyle J. Card,Misty D. Thomas,Joseph L. Graves,Jeffrey E. Barrick,Richard E. Lenski
标识
DOI:10.1073/pnas.2016886118
摘要
Significance A fundamental question in evolution is the repeatability of adaptation. Will independently evolving populations respond similarly when facing the same environmental challenge? This question also has important public-health implications related to the growing problem of antibiotic resistance. For example, efforts to control resistance might benefit from accurately predicting mutational paths to resistance. However, this goal is complicated when a lineage’s prior history alters its subsequent evolution. We recently found that differences between genetic backgrounds can lead to unpredictable responses in phenotypic resistance. Here, we report that genetic background can similarly alter genotypic paths to resistance. This historical contingency underscores the importance of accounting for stochasticity, in the past as well as at present, when designing evolutionarily informed treatment strategies.
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